拉贝洛尔在妊娠高血压综合征血压控制中的应用效果及对患者肾功能和心功能与血清炎症因子水平的影响  

The application effect of labetalol on blood pressure control in patients with pregnancy-induced hypertension syndrome and its impact on the renal function and cardiac function and serum inflammatory factors levels

作　　者：陈玲[1] 刘晓文 陈志方[1] CHEN Ling;LIU Xiaowen;CHEN Zhifang(Department of Obstetrics and Gynecology,Fengcheng People's Hospital,Yichun,Jiangxi,331100,China)

机构地区：[1]丰城市人民医院产科,江西宜春331100

出　　处：《当代医学》2024年第5期37-41,共5页Contemporary Medicine

摘　　要：目的探究拉贝洛尔在妊娠高血压综合征控制中的应用效果及对患者肾功能、心功能、血清炎症因子水平的影响。方法选取2020年1月至2022年4月丰城市人民医院收治的82例妊娠高血压综合征患者作为研究对象,根据随机数字表法分为A组与B组,每组41例。A组给予硫酸镁治疗,B组给予硫酸镁联合拉贝洛尔治疗,比较两组治疗前后血压水平、肾功能指标、心功能指标、血清炎症因子水平、血液流变学指标及不良妊娠结局发生情况。结果治疗后,B组收缩压(SBP)、舒张压(DBP)水平均低于A组,差异有统计学意义(P<0.05);治疗后,B组血尿素氮(BUN)、血肌酐(SCr)、胱抑素C(CysC)、24 h尿蛋白水平均低于A组,差异有统计学意义(P<0.05);治疗后,B组心肌肌钙蛋白(ⅠcTnⅠ)、B型脑钠肽(BNP)水平均低于A组,差异有统计学意义(P<0.05);治疗后,B组C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平均低于A组,差异有统计学意义(P<0.05);治疗后,B组全血黏度(WBV)与全血还原黏度(WBRV)低、中、高切水平均低于A组,差异有统计学意义(P<0.05);B组不良妊娠结局发生率为9.76%,低于A组的26.83%,差异有统计学意义(P<0.05)。结论拉贝洛尔治疗妊娠期高血压综合征效果显著,可降低患者血压水平,改善其心功能、肾功能、炎症因子水平及血液流变学指标,降低不良妊娠结局发生率。Objective To explore the application effect of labetalol on blood pressure control in patients with pregnancy-induced hypertension syndrome and its impact on renal function,cardiac function and serum inflammatory factors levels.Methods 82 patients with pregnancy-induced hypertension syndrome admitted to Fengcheng People's Hospital from January 2020 to April 2022 were selected as the research subjects,they were divided into the group A and the group B according to the random number table method,with 41 cases in each group.Group A was treated with magnesium sulfate and group B was treated with magnesium sulfate combined with labetalol,the blood pressure levels,renal function indicators,cardiac function indicators,serum inflammatory factor levels,hemorheological indicators before and after treatment,and adverse pregnancy outcomes were compared between the two groups.Results After treatment,the levels of systolic blood pressure(SBP)and diastolic blood pressure(DBP)in the group B were lower than those in the group A,and the differences were statistically significant(P<0.05);after treatment,the blood urea nitrogen(BUN),serum creatinine(SCr),cystatin C(CysC),and 24 h urine protein levels in the group B were lower than those in the group A,and the differences were statistically significant(P<0.05);after treatment,the cardiac troponin I(cTnI)and brain natriuretic peptide(BNP)levels in the group B were lower than those in the group A,and the differences were statistically significant(P<0.05);after treatment,the levels of C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)in the group B were lower than those in the group A,and the differences were statistically significant(P<0.05);after treatment,the levels of whole blood viscosity(WBV)and whole blood reduced viscosity(WBRV)at low,medium and high incision in the group B were significantly lower than those in the group A,and the differences were statistically significant(P<0.05);the incidence of adverse pregnancy outcomes in the group B was 9.76%,which was lower than

关 键 词：妊娠高血压综合征 拉贝洛尔 肾功能 心功能 炎症因子 血液流变学 

分 类 号：R714.246[医药卫生—妇产科学]