6项炎症指标对糖尿病发病风险的评估价值  

Research on the value of six biomarkers of inflammation to assess the risk of diabetes mellitus

作　　者：钱超 常琪 刘晨 吴瑞波 杨一龙 QIAN Chao;CHANG Qi;LIU Chen;WU Ruibo;YANG Yilong(Department of Clinical Laboratory,Air Force Hospital of Eastern Theater Command of PLA,Nanjing,Jiangsu,210002,China)

机构地区：[1]东部战区空军医院检验科,江苏南京210002

出　　处：《当代医学》2024年第5期147-150,共4页Contemporary Medicine

摘　　要：目的探讨WBC、C-反应蛋白(CRP)、补体C3、补体C4、白细胞介素(IL)-18和IL-6炎症指标在评估糖尿病发病风险及病情进展中的作用。方法选取2018年10月至2019年3月于东部战区空军医院体检中心172例体检者作为研究对象,根据糖化血红蛋白A1c(HbA1c)水平分为非糖尿病组(HbA1c<5.7%,n=49)、糖尿病前期组(HbA1c 5.7%~6.5%,n=95)及糖尿病组(HbA1c≥6.5%,n=28)。检测3组WBC、CRP、补体C3、补体C4、IL-18和IL-6炎症指标水平,同时检测3组空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)等指标水平,分析3组指标水平及炎症指标的差异及各指标与HbA1c水平的相关性。结果3组性别、年龄、体重指数(BMI)、舒张压、TC、LDL-C水平比较差异无统计学意义;3组收缩压、FBG、TG、HDL-C水平比较差异有统计学意义(P<0.05);糖尿病组收缩压及HbA1c、FBG、TG水平均高于糖尿病前期组、非糖尿病组,糖尿病组HDL-C水平低于糖尿病前期组、非糖尿病组,糖尿病前期组HbA1c、FBG水平及收缩压均高于非糖尿病组,差异有统计学意义(P<0.05)。3组WBC比较差异无统计学意义;3组CRP、补体C3、补体C4、IL-18、IL-6水平比较差异有统计学意义(P<0.05);糖尿病组血清IL-6、CRP、补体C3水平均高于非糖尿病组和糖尿病前期组,糖尿病组、糖尿病前期组血清补体C4和IL-18水平均高于非糖尿病组,差异有统计学意义(P<0.05)。Pearson相关性分析结果显示,HbA1c水平与收缩压、TG、IL-18和IL-6水平呈正相关(r>0,P<0.05),与HDL-C水平呈负相关(r<0,P<0.05)。结论随着糖尿病患者HbA1c水平的升高,炎症指标CRP、补体C3、补体C4、IL-18和IL-6水平逐步增高,IL-6和IL-18可作为T2DM早期的预测生物标志物,为评估糖尿病发病风险、病情进展提供依据。Objective To study the role of total WBC,C-reactive protein(CRP),complement C3,complement C4,interleukin(IL)-18 and IL-6 in evaluating the risk and progression of diabetes mellitus.Methods A total of 172 physical examiner in Air Force Hospital of Eastern Theater Command from October 2018 to March 2019 were selected as the study subjects,and they were divided into the non-diabetic group(glycosylated hemoglobin A1c[HbA1c]5.7%,n=49),pre-diabetic group(HbA1c 5.7%-6.5%,n=95)and diabetic group(HbA1c≥6.5%,n=28)according to the level of HbA1c.The inflammatory indicators levels of WBC,CRP,complement C3,complement C4,IL-18,IL-6 were detected among the three groups,while the baseline indicators levels of fasting blood glucose(FBG),total cholesterol(TC),triacylglycerol(TG),high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C)were also detected among the three groups.The difference of baseline indicators and inflammatory indicators among the three groups and the correlation between each indicator and HbA1c level were analyzed.Results There were no significant differences in sex,age,body mass index(BMI),diastolic blood pressure,TC and LDL-C among the three groups,there were significant differences in the levels of systolic blood pressure,FBG,TG and HDL-C among the three groups(P<0.05),the levels of systolic blood pressure,HbA1c,FBG,and TG in the diabetic group were higher than those in the pre-diabetic group and non-diabetic group,HDL-C in the diabetic group was lower than that in the pre-diabetic group and non-diabetic group,the levels of HbA1c,FBG and systolic blood pressure in the pre-diabetic group were higher than those in the non-diabetic group,and the differences were statistically significant(P<0.05).There was no significant difference in the levels of WBC among the three groups,there were significant differences in the levels of CRP,complement C3,complement C4,IL-18 and IL-6 among the three groups(P<0.05),the levels of serum IL-6,CRP and complement C3 in the diabetic group were hi

关 键 词：糖化血红蛋白A1C 白细胞介素-6 白细胞介素-18 炎症指标 

分 类 号：R587.1[医药卫生—内分泌]