奥沙利铂致急性胰腺炎1例  

Acute pancreatitis induced by oxaliplatin:one case report

作　　者：赵晨 周海辉[2] 王晶[1] ZHAO Chen;ZHOU Haihui;WANG Jing(Department of Pharmacy,Affiliated Nanjing Hospital of TCM,Nanjing University of TCM,Jiangsu Nanjing 210001,China;Department of Pharmacy,Affiliated Drum Tower Hospital,School of Medicine,Nanjing University,Jiangsu Nanjing 210008,China)

机构地区：[1]南京中医药大学附属南京中医院药学部,江苏南京210001 [2]南京大学医学院附属鼓楼医院药学部,江苏南京210008

出　　处：《中国医院药学杂志》2024年第9期1108-1110,共3页Chinese Journal of Hospital Pharmacy

摘　　要：药源性胰腺炎是由药物或代谢产物与机体之间异常相互作用引起的机体特异质反应或超敏反应而造成的胰腺损伤,发生率较低。奥沙利铂是第3代铂类抗肿瘤药物,常与5-FU和亚叶酸钙联合用于结直肠癌的治疗。奥沙利铂的主要不良反应为剂量限制性外周神经毒性、胃肠道反应和骨髓抑制等,关于其诱发急性胰腺炎的报道和讨论较少。本文就1例奥沙利铂致急性胰腺炎进行分析,旨在为防治该不良反应提供参考。Drug-induced pancreatitis is a rare disease characterized by specific reactions or hypersensitivity responses leading to pancreatic injuries.It results from abnormal interactions between drugs or their metabolites and human body.Oxaliplatin,a third-generation platinum-based anti-neoplasm agent,is commonly applied in combination with 5-fluorouracil and calcium folinate for colorectal cancer.The primary adverse reactions associated with oxaliplatin include dose-limiting peripheral neurotoxicity,gastrointestinal reactions and myelosuppression.There are few reports and discussions of its potential of inducing acute pancreatitis.This review focused upon one case of oxaliplatin-induced acute pancreatitis.It was intended to provide references for managing adverse reactions.

关 键 词：奥沙利铂 急性胰腺炎 不良事件 

分 类 号：R969.3[医药卫生—药理学]