斑马鱼模型在阿尔茨海默病研究中的应用  

Advancements in application of the zebrafish model of Alzheimer’s disease

作　　者：满海硕 陈红利 何悦[1] 孙雅煊 霍清[1] 戴雪伶 MAN Haishuo;CHEN Hongli;HE Yue;SUN Yaxuan;HUO Qing;DAI Xueling(Department of Food and Biomedicine,College of Biochemical Engineering,Beijing Union University,Beijing 100023,China)

机构地区：[1]北京联合大学生物化学工程学院食品与生物医药系,北京100023

出　　处：《中国实验动物学报》2024年第5期656-665,共10页Acta Laboratorium Animalis Scientia Sinica

基　　金：北京市自然科学基金项目(6164030);国家自然科学基金(11975048);北京联合大学教改项目(JY2023Y008)。

摘　　要：阿尔茨海默病(Alzheimer’s disease, AD)是一种中枢神经系统退行性疾病,主要表现为认知功能障碍、言语丧失等,其发病与多种因素有关。近年来,斑马鱼因其在大脑结构与功能、神经传导及AD致病基因等方面与人具有高度同源性而受到广泛关注。本文就斑马鱼作为动物模型探索AD发病机制、进行AD药物评估、药物筛选等方面的优势展开综述,以期为AD的发病机制及新药开发研究提供新思路。Alzheimer’s disease(AD)is a multifactorial degenerative disorder of the central nervous system that mainly manifests as cognitive dysfunction and loss of speech.In recent years,the zebrafish has attracted extensive attention because of its high homology with humans in terms of brain structure and function,nerve conduction,and pathogenic genes of AD.This article reviews the advantages of the zebrafish as an animal model of AD,covering topics in the pathogenesis of AD and the evaluation and screening of drugs for treatment of AD.The overall goal is to provide new insights into the pathogenesis of AD and development of novel drugs.

关 键 词：阿尔茨海默病 斑马鱼 发病机制 药物评估 药物筛选 

分 类 号：Q95-33[生物学—动物学]