论胆汁酸是非特异性肠炎的重要病因  

Bile Acid is the Main Cause of Nonspecific Inflammatory Bowel Diseases

作　　者：罗光云 段为钢 LUO Guangyun;DUAN Weigang(School of Basic Medicine,Yunnan University of Chinese Medicine,Kunming 650500,China)

机构地区：[1]云南中医药大学基础医学院,云南昆明650500

出　　处：《云南中医药大学学报》2024年第2期14-21,共8页Journal of Yunnan University of Chinese Medicine

基　　金：国家自然科学基金项目(82260886);云南省中医药联合专项(202101AZ070001-010,202101AZ070001-022)。

摘　　要：克罗恩病和溃疡性结肠炎是一组病因尚未阐明的慢性非特异性肠道炎症性疾病,临床治疗往往只能进行对症处理,疗效有限,经常迁延不愈,预后较差。为了寻求病因,本文从这组疾病的共性特征入手,结合其他胆汁酸所致疾病,得出其主要病因是较多的胆汁酸盐进入肠道腐蚀黏膜所致,同时可能伴有次级胆汁酸盐的毒性作用。因结肠细菌丰富继而发生感染、菌群失调和免疫失衡。胆汁源自肝木,小肠属火,大肠(结肠)属金,这种疾病的发生也可以用中医理论归纳为“木火蚀金”。本文对胆汁酸盐过多进入肠道的原因也进行了分析并提出新的治疗策略。Crohn's disease and ulcerative colitis are two kinds of nonspecific inflammatory bowel diseases with frequent morbidity.Due to their unclear etiology,the two diseases can be clinically controlled by symptomatic treatment with limited effects,and often the prognosis is frequently poor.In order to find out the main cause,based on the common characteristics of these two diseases,combined with the diseases caused by other bile acids or their salts,this paper concludes that the main cause the overloaded primary bile salts in the intestine that corrodes the intestinal mucosa,and the minor cause is associated with the secondary bile salts.Afterwards,due to the abundant colon bacteria,infection happens,and flora imbalance and immune imbalance occur.Because the liver,where the bile comes from,is Mu,the small intestine is Huo,and the colon is Jin,the occurrence of this disease can also be summarized as "Mu Huo corroding Jin" by traditional Chinese medicine theory.The causes of excessive bile salts entering the intestine were also analyzed and a new treatment strategy was proposed.

关 键 词：非特异肠炎 克罗恩病 溃疡性结肠炎 黏膜损伤 胆汁 胆汁酸盐 木火蚀金 

分 类 号：R256.4[医药卫生—中医内科学]