2023年阿坝州2市县233名学龄前健康儿童肠道病毒携带调查结果分析  

Analysis of surey reswas on enterovirus carrying status among 233 healthy preschool children in 2 cities/counties of Aba Prefecture in 2023

作　　者：王文碧 马小珍[2] 丁颖 陈娜[2] WANG Wenbi;MA Xiaozhen;DING Ying;CHEN Na(Aba Center for Disease Control and Prevention,Maerkang 624000,Sichuan Province,China;Sichuan Center for Disease Control and Prevention,Chengdu 610041,Sichuan Province,China)

机构地区：[1]阿坝藏族羌族自治州疾病预防控制中心,四川马尔康624000 [2]四川省疾病预防控制中心,成都610041

出　　处：《预防医学情报杂志》2024年第5期535-538,549,共5页Journal of Preventive Medicine Information

摘　　要：目的了解阿坝藏族羌族自治州马尔康市和红原县2地健康儿童的肠道病毒(enterovirus,EV)携带状况及型别分布,为制订肠道病毒防控策略提供依据。方法2023年3月29日至2023年4月23日在阿坝藏族羌族自治州马尔康市和红原县各采集1家幼儿园对学龄前健康儿童粪便标本进行EV核酸检测并进行核苷酸序列测定,分析EV型别分布情况。使用SPSS 19.0软件对EV的检测结果进行统计学分析,组间比较采用χ^(2)检验,检验水准α=0.05(双侧)。结果共检测233名健康儿童中,EV核酸阳性检出52份,其中马尔康市阳性检出率为25.2%(31/123),红原县为19.1%(21/110):男性EV阳性检出率为24.6%(28/114),女性为21.2%(24/113),性别之间EV阳性检出率差异无统计学意义(χ^(2)=0.355,P=0.551)。3岁年龄组EV阳性检出率为30.7%(23/75),4岁年龄组为27.6%(21/76),5岁年龄组为9.8%(8/82),各年龄组EV阳性检出率差异有统计学意义(χ^(2)=11.717,P=0.003)。52份EV核酸阳性标本共鉴定出10种型别EV,其中马尔康市9种,红原县7种。10种型别EV中CV B2占比38.5%(20/52),E6和CV A6占比均为17.3%(9/52),CV A4占比11.5%(6/52),CV A2和CV A5占比均为3.8%(2/52),CV A13和CV A19、E29、E9占比均为1.9%(1/52)。结论阿坝藏族羌族自治州马尔康市和红原县2地学龄前尤其是5岁以下健康儿童EV隐性感染率较高,CV B2为主要流行株;CV B2、E6在1家幼儿园的多份标本中检出,提示局部存在密切接触传播。应加强学龄前儿童健康教育及防控措施的落实,减少感染机会,降低肠道病毒的感染率。Objective To survey the enterovirus(EV)carrying status and type distribution among healthy children in Maerkang City and Hongyuan County of Aba Tibetan and Qiang Autonomous Prefecture,and to provide basis for formulating enterovirus prevention and control strategy.Methods From March29,2023 to April 23,2023,stool samples were collected from healthy preschool children in one kindergarten in Maerkang City and Hongyuan County of Aba Tibetan and Qiang Autonomous Prefecture,respectively,for EV nucleic acid detection and nucleotide sequence analysis to analyze EV type distribution.The results of EV detection were analyzed by SPSS 19.0 software.Group comparisons were conducted byχ^(2)test.The test level wasα=0.05(bilateral).Results A total of233 healthy children were tested,and 52 samples were positive for EV nucleic acid.The positive detection rate was 25.2%(31/123)in Maerkang City and 19.1%(21/110)in Hongyuan County,respectively.The positive detection rate of EV was 24.6%(28/114)in males and 21.2%(24/113)in females,and there was no significant difference in the EV positive detection rate between males and females(χ^(2)=0.355,P=0.551).The EV positive detection rate was 30.7%(23/75)in the 3-year age group,27.6%(21/76)in the 4-year age group,and 9.8%(8/82)in the 5-year age group.There were significant differences in EV detection rate among all age groups(χ^(2)=11.717,P=0.003).A total of 10 types of EV were identified from the 52 samples that tested positive for EV nucleic acid,among which,Maerkang City had 9 types and Hongyuan County had 7 types.Among these10 types,CV B2 accounted for 38.5%(20/52),E6 and CV A6 accounted for17.3%(9/52),respectively,CV A4 accounted for 11.5%(6/52),CV A2 and CV A5 accounted for 3.8%(2/52),and CV A13,CV A19,E29 and E9 accounted for 1.9%(1/52),respectively.Conclusions The latent infection rate of EV in preschool children,especially healthy children under 5 years old in Maerkang City and Hongyuan County in Aba Tibetan and Qiang Autonomous Prefecture was high,and CVB2 was the main prevalent

关 键 词：健康儿童 肠道病毒 型别分布 

分 类 号：R725.1[医药卫生—儿科] R181.3[医药卫生—临床医学]