青霉素治疗钩端螺旋体病引起赫氏反应一例  

Leptospirosis with Jarisch-Herxheimer reaction:a case report

作　　者：周颖 胡静 ZHOU Ying;HU Jing(Department of Pharmacy,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210000,China)

机构地区：[1]南京医科大学第一附属医院药学部,南京210000

出　　处：《临床药物治疗杂志》2024年第5期90-92,共3页Clinical Medication Journal

摘　　要：本文报告1例53岁患者,以发热、咳嗽咳痰、痰中带血、伴有呼吸功能障碍、影像学显示弥漫性肺泡出血、双下肢肌肉酸痛、肝功能损害、黄疸为主要临床表现,宏基因二代测序技术检测到肾脏钩端螺旋体,后确诊为钩端螺旋体病,并在使用青霉素治疗过程中出现赫氏反应。临床药师协助医师,提供合适的抗感染方案以及赫氏反应的识别和处置意见,患者病情转归良好出院。This article presents a 53-year-old patient who presented with fever,cough with bloody sputum,respiratory dysfunction,diffuse alveolar hemorrhage on imaging,muscle soreness in both lower limbs,liver dysfunction,and jaundice as the main clinical manifestations.Leptospira interrogans was detected by next-generation sequencing.The patient was later diagnosed with leptospirosis,and Jarisch-Herxheimer reaction(JHR)occurred during the treatment with penicillin.Clinical pharmacists assisted in providing appropriate antimicrobial therapy,as well as the identification and treatment of JHR.Then the patient's condition was improved and finally discharged from the hospital.

关 键 词：钩端螺旋体 青霉素 赫氏反应 

分 类 号：R978.4[医药卫生—药品]