基于EIT的不同体位下肺通气、肺灌注区域分布和通气/灌注匹配研究  

EIT-based study of lung ventilation and perfusion regional distribution and ventilation/perfusion matching in different body positions

作　　者：韩悌昕 刘亦凡 代萌 王普 叶健安 赵志博 招展奇 付峰 HAN Ti-xin;LIU Yi-fan;DAI Meng;WANG Pu;YE Jian-an;ZHAO Zhi-bo;ZHAO Zhan-qi;FU Feng(Military Biomedical Engineering School,Air Force Medical University,Xi'an 710032,China;Shaanxi Key Laboratory of Bio-electromagnetic Detection and Intelligent Sensing,Xi'an 710032,China;School of Biomedical Engineering,Guangzhou Medical University,Guangzhou 511436,China)

机构地区：[1]空军军医大学军事生物医学工程学系,西安710032 [2]陕西省生物电磁检测与智能感知重点实验室,西安710032 [3]广州医科大学生物医学工程学院,广州511436

出　　处：《医疗卫生装备》2024年第5期1-7,共7页Chinese Medical Equipment Journal

基　　金：国家重点研发计划项目(2022YFC2404801);国家自然科学基金重点项目(51837011)。

摘　　要：目的:基于电阻抗断层成像(electrical impedance tomography,EIT)比较不同体位下的肺通气、肺灌注区域分布和通气/灌注(V/Q)匹配情况。方法:选取10只健康实验猪,采集其仰卧位、俯卧位、左侧卧位、右侧卧位下的EIT肺部通气和血流灌注数据。使用MATLAB R2022b,基于EIDORS v3.9进行EIT数据分析和图像重构,以最大像素值20%作为阈值确定具有通气和灌注的有效区域,并进行V/Q匹配区域计算。比较不同体位下V/Q匹配评价指标(匹配分数%、死腔分数%、分流分数%)及通气、灌注区域在不同感兴趣区域(ROI1、ROI2、ROI3、ROI4)内的分布。结果:实验动物在不同体位下的匹配分数%、死腔分数%、分流分数%差异无统计学意义(P>0.05)。在不同体位下,通气、灌注的区域分布发生改变,通气区域在ROI1、ROI2、ROI3分布差异有统计学意义(P<0.05),灌注区域在ROI1、ROI2分布差异有统计学意义(P<0.05)。在仰卧位和俯卧位下,通气、灌注区域分布呈现出与重力依赖区分布一致的现象,而在右侧卧位和左侧卧位下,通气、灌注区域分布则呈现出与重力依赖区分布相反的现象。结论:同一实验对象在不同体位下的全局V/Q匹配参数具有较好的检验一致性;测量体位的变化将导致肺重力依赖区的变化,进而影响局部肺通气和肺灌注区域的分布;EIT能够对体位改变导致的肺通气、肺灌注改变进行测定,明确体位变化对肺通气、肺灌注和V/Q匹配的影响。Objective To compare regional pulmonary ventilation and perfusion and ventilation/perfusion(V/Q)matching in different body positions using electrical impedance tomography(EIT).Methods Ten healthy experimental pigs were selected to collect their EIT lung ventilation and perfusion data in supine,prone,left lateral and right lateral positions.The EIT data underwent analysis and image reconstruction using MATLAB R2022b and EIDORS v3.9.The effective regions with ventilation and perfusion were determined and the V/Q matching regions were computed with the maximum pixel value 20%as the threshold.Comparisons were carried out over the V/Q matching indexes including V/Q match%,dead space%and shunt%and ventilation and perfusion distribution in regions of interest(ROIs)including ROI1,ROI2,ROI3 and ROI4 in different body positions.Results The differences in V/Q match%,dead space%and shunt%of the experimental animals in varied positions were not statistically significant(P>0.05).The regional distribution of pulmonary ventilation and perfusion changed in different positions,and the regional distributions differed in ROI1,ROI2 and ROI3 for ventilation(P<0.05)and in ROI1 and ROI2 for perfusion(P<0.05).The ventilation and perfusion regions were distributed consistently with the gravity-dependent areas in supine and prone positions whereas conversely in the right and left lateral positions.Conclusion The V/Q matching indexes of one subject have high test consistency in different body positions;gravity-dependent areas varied with the changes of the body positions,which affected the distribution of pulmonary ventilation and perfusion regions;EIT can be used for measuring the changed pulmonary ventilation and perfusion due to different positions and determining the influences of position changes on pulmonary ventilation and perfusion and V/Q matching.

关 键 词：电阻抗断层成像 体位变化 肺通气 肺灌注 V/Q匹配 

分 类 号：R318[医药卫生—生物医学工程]