PTW Detector7293种剂量验证方法在调强放射治疗中的对比研究  

Comparison of three dose verification methods in intensity modulated radiation therapy using PTW Detector729

作　　者：吴晓辉 姚祖文 徐珊珊 罗桃红 胡小容[1] 姚阳[1] 王晓华[1] WU Xiao-hui;YAO Zu-wen;XU Shan-shan;LUO Tao-hong;HU Xiao-rong;YAO Yang;WANG Xiao-hua(Department of Radiation Oncology,Cancer Center of Suining Central Hospital,Suining 629018,Sichuan Province,China;Department of Nutrition,Suining Central Hospital,Suining 629099,Sichuan Province,China)

机构地区：[1]遂宁市中心医院肿瘤中心放射治疗科,四川遂宁629018 [2]遂宁市中心医院营养科,四川遂宁629099

出　　处：《医疗卫生装备》2024年第5期56-59,共4页Chinese Medical Equipment Journal

摘　　要：目的 :对比PTW Detector729 3种验证方法在调强放射治疗(intensity modulated radiation therapy,IMRT)剂量验证中的差异。方法:回顾性选取2022年1—12月于某院完成放射治疗的鼻咽癌、肺癌、乳腺癌、宫颈癌和全脑放射治疗患者共50例,使用PTW Detector729二维电离室矩阵配合PTW RW3固体水与PTW Ocavius 4D旋转模体对50例患者的IMRT计划分别进行归零机架角2D剂量验证、实际机架角2D剂量验证和实际机架角3D剂量验证。将剂量评估阈值设为10%,统计3种验证方法在3%/1 mm、2%/2 mm、3%/2 mm和3%/3 mm 4种评估标准下的γ通过率。采用SPSS 22.0统计学软件进行数据分析。结果:在10%剂量评估阈值标准下,归零机架角2D剂量验证的γ通过率最高,差异有统计学意义(P<0.05);实际机架角2D剂量验证的γ通过率高于实际机架角3D剂量验证,差异有统计学意义(P<0.05)。3种验证方法的γ通过率在3%/1 mm、2%/2 mm、3%/2 mm和3%/3 mm 4种标准下逐渐升高,且在3%/2 mm标准下均超过90%,结果满足临床放射治疗要求。结论:3种验证方法的验证结果均能达到IMRT剂量验证实践指南要求,根据IMRT开展情况选择合适的验证方法,对确保治疗方案安全、有效实施具有重要意义。Objective To compare the three methods in intensity modulated radiation therapy(IMRT)dose verification using PTW Detector729.Methods A total of 50 patients with nasopharyngeal cancer,lung cancer,breast cancer,cervical cancer and whole brain radiation therapy who completed radiation treatment at some hospital from January to December 2022 were selected retrospectively.Two-dimensional(zero and actual gantry angles)and three-dimensional dose verifications were carried out for the IMRT plans using PTW Detector7292D ionization chamber matrix combined with PTW RW3 solid water and PTW Ocavius 4D rotation unit.The dose assessment threshold was set to 10%,and theγpass rates of the three verification methods were counted under four assessment criteria,namely 3%/1 mm,2%/2 mm,3%/2 mm and 3%/3 mm.SPSS 22.0 statistical software was used for data analysis.Results Under the 10%dose assessment threshold criterion,zero-gantry-angle 2D dose verification had the highestγpass rate,and the differences were statistically significant(P<0.05);actual-gantry-angle 2D dose verification had theγpass rate higher than that of 3D verification,and the differences were statistically significant(P<0.05).Theγpass rates of the three verification methods gradually increased under four criteria,namely,3%/1 mm,2%/2 mm,3%/2 mm and 3%/3 mm,and exceeded 90%under the 3%/2 mm criterion,and the results met the requirements of clinical radiotherapy.Conclusion The results of the three verification methods satisfy the requirements of the IMRT dose verification practice guidelines,and the selection of appropriate verification methods is of great significance to ensure the implementation of the treatment plan.

关 键 词：PTW Detector729 二维电离室矩阵 剂量验证 γ通过率 调强放射治疗 

分 类 号：R318[医药卫生—生物医学工程] R815[医药卫生—基础医学]