莫西沙星联合多药治疗耐多药肺结核的临床疗效及对炎性因子、免疫功能的影响  

Clinical Efficacy of Moxifloxacin Plus Multidrug Therapy in MDR Tuberculosis and its Effect on Inflammatory Factors Level and Immune Function

作　　者：朱晶 吴俊杰 陈银松 Zhu Jing;Wu Junjie;Chen Yinsong(Department of Tuberculosis,The Third People's Hospital of Yangzhou,Yangzhou Jiangsu 225000,China)

机构地区：[1]扬州市第三人民医院结核科,江苏扬州225000

出　　处：《生命科学仪器》2024年第1期171-173,共3页Life Science Instruments

摘　　要：目的探讨莫西沙星联合多药治疗耐多药肺结核的临床效果及对炎性因子、免疫功能的影响。方法选择2021年2月至2023年11月扬州市第三人民医院诊治的耐多药肺结核患者78例,以随机数表法分为对照组与观察组,各39例。对照组采取常规化疗治疗,观察组在此基础上加用莫西沙星治疗。对比两组临床疗效、炎性因子与免疫功能。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组治疗后炎性因子水平均更低,差异有统计学意义(P<0.05)。观察组治疗后各项免疫功能指标均更优,差异有统计学意义(P<0.05)。结论莫西沙星联合多药治疗耐多药肺结核可取得良好疗效,对患者炎性反应、免疫功能均具有明显的改善作用。Objective:To Objective to explore the clinical effect of moxifloxacin combined with multi-drugs in the treatment of multi-drug resistant pulmonary tuberculosis and its influence on inflammatory factors and immune function.Methods:From February 2021 to November 2023,78 patients with multidrug-resistant pulmonary tuberculosis in Yangzhou Third People's Hospital were selected and randomly divided into control group and observation group,with 39 cases in each group.The control group was treated with routine chemotherapy,and the observation group was treated with moxifloxacin on the basis of this.The clinical efficacy,inflammatory factors and immune function of the two groups were compared.Results:The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The levels of inflammatory factors in the observation group were all lower after treatment,and the difference was statistically significant(P<0.05).After treatment,all immune function indexes in the observation group were better,and the difference was statistically significant(P<0.05).Conclusion:Moxifloxacin combined with multi-drugs can achieve good curative effect in the treatment of multi-drug resistant pulmonary tuberculosis,and can obviously improve the inflammatory response and immune function of patients.

关 键 词：莫西沙星 耐多药肺结核 临床疗效 炎性因子 免疫功能 

分 类 号：R521[医药卫生—内科学]