PDR抗VEGF药物眼内注射后玻璃体切割术的临床价值分析  

Clinical value of vitrectomy after intraocular injection of anti-VEGF drugs on PDR

作　　者：陈娇娇 林胜亭 Chen Jiaojiao;Lin Shengting(Shuyang Hospital of Traditional Chinese Medicine,Shuyang 223600,China)

机构地区：[1]江苏省沭阳县中医院,江苏沭阳223600

出　　处：《生命科学仪器》2024年第1期213-215,共3页Life Science Instruments

摘　　要：目的探究增生性糖尿病视网膜病变(PDR)抗心血管生长因子(VEGF)药物眼内注射后玻璃体切割术的临床价值。方法将2020年1月~2022年3月我院收治的84例PDR患者(共84只眼)作为研究对象,按照简单随机法将研究对象分为对照组(n=42)和观察组(n=42)。对照组以玻璃体切割术(PPV)治疗,观察组在对照组的基础上,PPV术前在玻璃体腔内注射抗VEGF药物。评估两组患者手术情况及并发症发生率(手术时间以及出血、电凝止血、医源性裂孔发生率),评估术前、术后7d、术后3月两组患者视力情况[最佳矫正视力(BCVS)]以及黄斑中心凹视网膜厚度(CMT)差异。结果手术期间,观察组患者手术时间、出血率低于对照组(P<0.05);术后7d、术后3月两组患者CMT均低于术前,观察组CMT低于对照组(P<0.05);术后7d、术后3月两组患者BCVA均优于术前,观察组BCVA优于对照组(P<0.05)。结论PDR患者眼内注射抗VEGF的药物后实施PPV能有效降低手术时间以及手术中出血率,有效改善患者CMT以及BCVA。Objective:To investigate the clinical value of vitrectomy after intraocular injection of anti-vascular endothelial growth factor(VEGF)drugs on proliferative diabetic retinopathy(PDR).Methods:84 patients(84 eyes)with PDR in the hospital from January 2020 to March 2022 were enrolled in the study.The subjects were divided into control group(n=42)and observation group(n=42)according to the simple randomization method.The control group was treated with pars plana vitrectomy(PPV),while the observation group was added with intravitreal injection of anti-VEGF drugs before PPV on the basis of the control group.The surgical conditions and incidence rates of complications(surgical time and incidence rates of bleeding,electrocoagulation hemostasis,iatrogenic retinal breaks)and visual acuity status[best corrected visual acuity(BCVS)]and central macular retinal thickness(CMT)before surgery and at 7 days and 3 months after surgery were evaluated in both groups.Results:During surgery,the surgical time and bleeding rate in observation group were shorter or less than those in control group(P<0.05).The CMT in the two groups at 7 days and 3 months after surgery was thinner than that before surgery,and the CMT was thinner in observation group(P<0.05).The BCVA was better in the two groups at 7 days and 3 months after surgery than that before surgery,and the observation group had better BCVA than that in control group(P<0.05).Conclusion:PPV after intraocular injection of anti-VEGF drugs in patients with PDR can effectively shorten the surgical time,reduce the intraoperative bleeding rate,and effectively improve the CMT and BCVA.

关 键 词：增生性糖尿病视网膜病变 心血管生长因子 玻璃体切割术 最佳矫正视力 

分 类 号：R587.1[医药卫生—内分泌]