不同运动强度与骨关节炎发病风险的效应分析  

Causal effects of different exercise intensities on the risk of osteoarthritis

作　　者：马浩宇 乔鸿超 郝茜茜 史冬博[1] Ma Haoyu;Qiao Hongchao;Hao Qianqian;Shi Dongbo(College of Physical Education,Taiyuan University of Technology,Jinzhong 030600,Shanxi Province,China)

机构地区：[1]太原理工大学体育学院,山西省晋中市030600

出　　处：《中国组织工程研究》2025年第6期1305-1311,共7页Chinese Journal of Tissue Engineering Research

摘　　要：背景:越来越多的证据表明不同运动强度与骨关节炎风险之间存在关联,但这可能受到混杂和反向因果关系的影响,结论尚未统一。目的:应用孟德尔随机化探索不同运动强度与骨关节炎的因果关联。方法:选取与不同运动强度相关联的全基因组关联研究数据,以阈值P<5×10-8筛选工具变量,采用孟德尔随机化5种分析方法评估暴露与结局风险的因果关系,以逆方差加权法作为主要分析方法。使用选定的工具变量来评估不同运动强度与骨关节炎的因果关联,并进行敏感性分析与反向孟德尔随机化分析。结果与结论:①逆方差加权法分析结果显示,低强度运动对膝骨关节炎的保护效应显著(OR=0.14,95%CI:0.06-0.32,P<0.001),久坐行为(例如电视观看)是膝骨关节炎和髋骨关节炎的危险因素(OR=2.24,95%CI:1.74-2.88,P<0.001;OR=1.34,95%CI:1.01-1.78,P=0.04)。对于骨关节炎与不同运动强度的反向孟德尔随机化分析发现,骨关节炎与低强度运动呈负相关性,与电视观看呈正相关。②分析结果显示,不同运动强度与骨关节炎风险存在双向因果关系。BACKGROUND:Increasing evidence supports the association between different exercise intensities and the risk of osteoarthritis,but this may be affected by confounding and reverse causality,and the conclusions have not been unified.OBJECTIVE:To explore the causal association between different exercise intensities and osteoarthritis using Mendelian randomization method.METHODS:Data from genome-wide association studies associated with different exercise intensities were selected,and instrumental variables were screened with a threshold of P<5×10-8.Causal associations between exposure and risk of outcome were assessed using five analysis methods of Mendelian randomization with inverse variance weighting as the primary analysis method.Selected instrumental variables were used to assess causal associations between different exercise intensities and osteoarthritis,and sensitivity analyses with inverse Mendelian randomization were performed.RESULTS AND CONCLUSION:In the analysis results of the inverse variance weighting method,low-intensity exercise showed a significant protective effect on knee osteoarthritis[odds ratio(OR)=0.14,95%confidence interval(CI):0.06-0.32,P<0.001],while sedentary behavior without exercise intensity,such as watching TV,was confirmed to be a risk factor for knee osteoarthritis and hip osteoarthritis(OR=2.24,95%CI:1.74-2.88,P<0.001;OR=1.34,95%CI:1.01-1.78,P=0.04).Through the reverse Mendelian randomization analysis of osteoarthritis to different exercise intensities,it was found that osteoarthritis was negatively correlated with low-intensity exercise and positively correlated with watching TV.The analysis results show that there is a two-way causal relationship between different exercise intensity and osteoarthritis risk.

关 键 词：运动强度 骨关节炎 孟德尔随机化 因果关联 膝骨关节炎 髋骨关节炎 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R684.3