诱导排卵失败对冻融胚胎移植妊娠结局的影响  

Effects of failed ovulation induction on reproductive outcomes in frozen-thawed embryo transfer

作　　者：王涛 王辉 师娟子 范丽娟 WANG Tao;WANG Hui;SHI Juan-zi;Fan Li-juan(Northwest Women’s&Children’s Hospital,Xi’an 710000;Shaanxi Provincial Clinical Research Center for Gynecological Diseases,Xi’an 710000)

机构地区：[1]西北妇女儿童医院辅助生殖中心,西安710000 [2]陕西省妇科疾病临床研究中心,西安710000

出　　处：《生殖医学杂志》2024年第6期722-727,共6页Journal of Reproductive Medicine

基　　金：陕西省陕西省重点产业链项目(2023-ZDLSF-48);陕西省卫生健康生殖医学科研创新团队(2023TD-04)。

摘　　要：目的探讨在稀发排卵或无排卵女性群体中,诱导排卵(OI)失败转人工周期(AC)治疗对冻融胚胎移植(FET)妊娠结局的影响,并分析影响OI成败的危险因素。方法回顾性分析2018年1月至2022年3月于西北妇女儿童医院行首次FET治疗的478例患者的临床资料,根据促排卵治疗结果分为OI成功组(277例)和OI失败组(201例),比较两组的临床妊娠率和活产率,Logistic回归分析影响OI成败的危险因素。结果两组患者的临床妊娠率(62.45%vs.59.70%)和活产率(53.43%vs.51.74%)均无显著差异(P>0.05);OI失败组的基础LH水平显著高于OI成功组(P=0.03)。调整变量后,发现基础LH水平是影响OI成败的独立影响因素[OR=1.079,95%CI(1.020,1.141),P=0.008]。结论稀发排卵或无排卵女性FET移植前OI成败与妊娠结局无关。基础LH水平是OI成败的影响因素。Objective:To investigate the association between ovulation induction(OI)failure and the outcomes of frozen-thawed embryo transfers(FET)in oligo-ovulation and non-ovulation women,and to explore the risk factors of OI failure.Methods:This retrospective study included women who attempted their first FET at Northwest Women’s&Children’s Hospital between January 2018 and March 2022.A total of 478 patients were included in this study,of which 277(57.95%)were in the OI success group and 201(42.05%)were in the OI failure group according to the outcomes of OI.The primary outcomes were clinical pregnancy rate and live birth rate.Logistic analysis was utilized to find out the risk factors of OI failure.Results:The clinical pregnancy rate(62.45%vs.59.70%)and the live birth rate(53.43%vs.51.74%)of the two groups were similar(P>0.05).The basal LH levels in the OI failure group were significantly higher than those in the OI success group(P=0.03).After adjusting the variables,it was found that baseline LH level was an independent risk factor of OI failure[OR=1.079,95%CI(1.020,1.141),P=0.008].Conclusions:There were no effects of OI failure before FET on pregnancy outcomes in oligo-ovulation and non-ovulation women,and the basal LH level was an independent risk factor of OI failure.

关 键 词：冻融胚胎移植 诱导排卵 人工周期 妊娠结局 

分 类 号：R711.6[医药卫生—妇产科学]