苄星青霉素配合常规治疗新生儿先天性梅毒的临床效果  

Clinical efficacy of benzylpenicillin combined with routine therapy for congenital syphilis in newborns

作　　者：张秋凤 韩雪梅[1] 李亚婷[1] 张伟 谭鸿双 罗寒依 ZHANG Qiufeng;HAN Xuemei;LI Yating;ZHANG Wei;TAN Hongshuang;LUO Hanyi(Department of Neonatology,Guangyuan Maternal and Child Health Hospital,Guangyuan,Sichuan 628000,China;不详)

机构地区：[1]广元市妇幼保健院新生儿科,四川广元628000 [2]成都市妇女儿童中心医院

出　　处：《医学动物防制》2024年第6期623-624,F0003,F0004,共4页Journal of Medical Pest Control

基　　金：2020年四川省卫生和计划生育委员会科研课题(重点研究项目)立项课题(20ZD019)。

摘　　要：目的对新生儿先天性梅毒采用苄星青霉素配合常规治疗的疗效进行探讨。方法回顾性分析广元市某医院2008年8月—2018年9月收治的90例先天性梅毒新生儿的临床资料,苄星青霉素配合常规治疗的(A组)患儿48例,青霉素配合常规治疗的(B组)患儿42例。对比两组患儿治疗后的临床疗效及康复情况。并对计数资料进行t检验,对等级资料进行秩和检验,对占比进行χ^(2)检验。结果A组患儿的皮疹消退时间、黄疸消退时间、血小板计数恢复正常时间均短于B组(t=4.290、2.623、3.597,P<0.05);A、B组患儿的临床疗效分布差异有统计学意义(Z=4.087,P<0.05),A组患儿的总有效率高于B组(χ^(2)=3.889,P<0.05);A组患儿治疗后6个月、12个月的快速血浆反应素(rapid plasma reagin,RPR)环状卡片试验转阴率均高于B组(χ^(2)=7.144、6.221,P<0.05);治疗后两组患儿的身体发育情况差异有统计学意义(Z=4.529,P<0.05),A组患儿身体发育正常率高于B组(χ^(2)=4.402,P<0.05)。结论在先天性梅毒新生儿患者中实施苄星青霉素配合常规治疗可促进其康复,增强疗效,改善预后,促进其生长发育。Objective To discuss the clinical effectiveness of benzylpenicillin combined with routine therapy for congenital syphilis in newborns.Methods A retrospective analysis was made of the clinical data of 90 newborns with congenital syphilis admitted to a hospital in Guangyuan from August 2008 to September 2018.Among them,48 were treated with benzylpenicillin combined with routine therapy(group A),and 42 were treated with penicillin combined with conventional treatment(group B).Clinical efficacy and rehabilitation were compared between the two groups after treatment.The t test was used for enumeration data,rank sum test was used for ranked data,and Chi-square test was used for proportion.Results The time of skin rash subsidence,jaundice subsidence time and platelet count recovery in children in group A were shorter than those in group B(t=4.290,2.623 and 3.597,P<0.05).There was a statistically significant difference in the distribution of clinical efficacy between children in A and B groups(Z=4.087,P<0.05),and the total effective rate of children in group A was higher than that of group B(χ^(2)=3.889,P<0.05).The negative rates of rapid plasma reagin(RPR)circle card test between children in group A 6 months and 12 months after treatment were higher than those of group B(χ^(2)=7.144,6.221,P<0.05).After treatment,there was a statistically significant difference in the distribution of physical development between the children in two groups(Z=4.529,P<0.05),and the normal rate of physical development in children of group A was higher than that of group B(χ^(2)=4.402,P<0.05).Conclusion Benzylpenicillin combined with routine therapy can promote rehabilitation,enhance curative effect,improve prognosis and promote growth and development in newborns with congenital syphilis.

关 键 词：苄星青霉素 常规治疗 先天性梅毒 效果 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]