新生儿呼吸窘迫综合征雾化吸入疗法的定量分析  

Quantitative Analysis of Nebulized Inhalation Therapy for Neonatal Respiratory Distress Syndrome

作　　者：刘伟华 解谦[2] 周雅玲 LIU Weihua;XIE Qian;ZHOU Yaling(College of Science,Harbin University of Science and Technology,Harbin 150080,China;Department of Pediatrics,Heilongjiang Province Hospital,Harbin 150036,China)

机构地区：[1]哈尔滨理工大学理学院,哈尔滨150080 [2]黑龙江省医院儿科,哈尔滨150036

出　　处：《哈尔滨理工大学学报》2024年第1期124-132,共9页Journal of Harbin University of Science and Technology

基　　金：黑龙江省自然科学基金(A2016004).

摘　　要：新生儿呼吸窘迫综合征(NRDS)的治疗是将肺表面活性物质(PS)通过有创或无创方式作用到肺部。本文基于药物动力学原理和给药方式,建立了对新生儿无创伤的雾化吸入PS治疗NRDS的数学模型,定量分析雾化吸入PS后血氧分压(PaO_(2))的变化。针对新生儿雾化吸入PS用药方案,以PaO_(2)控制在正常值范围内为约束,数值模拟了PaO_(2)变化规律,发现雾化吸入与气管插管疗效相近,但无创是其优势。模型还可模拟出NRDS个性PS用药后PaO_(2)变化趋势,因而为临床应用雾化吸入技术提供了理论依据。To treat neonatal respiratory distress syndrome(NRDS)is to deliver pulmonary surfactant(PS)to lungs with either invasive or non-invasive methods.This paper,based on the pharmacokinetic principles and administration ways,established a mathematical model of nebulized inhalation of PS for the treatment of NRDS,which was non-invasive for the newborn,to quantitatively analyze the fluctuation of blood oxygen partial pressure(PaO_(2))after medication.For the regimen of the newborn’s nebulized inhalation of PS,after simulating the variation of PaO_(2) with data limited within a normal range,this paper found that nebulized inhalation was similarly effective as endotracheal intubation,and that the former prevailed for its non-invasiveness.It could also simulate the changing trend of PaO_(2) after personal PS medication of NRDS,which has thus provided a theoretical backup for the clinical application of atomization inhalation technology.

关 键 词：呼吸窘迫综合征 雾化吸入数学模型 PS用药方案 PaO2数值模拟 

分 类 号：O715.1[理学—晶体学]