TYG指数、血小板参数及血清CK-MB水平与急性STEMI患者主要不良预后事件的相关性  

Correlation of TYG index,platelet parameters,serum CK-MB and major adverse cardiovascular events in patients with acute STsegment elevation myocardial infarction

作　　者：罗莉媛 王春彬[1] LUO Liyuan;WANG Chunbin(Department of Cardiology,the Third People's Hospital of Chengdu,Chengdu Sichuan 610000,China)

机构地区：[1]成都市第三人民医院心内科,四川成都610000

出　　处：《中国急救复苏与灾害医学杂志》2024年第6期718-721,共4页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：成都市医学科研课题(编号:2021307)。

摘　　要：目的分析三酰甘油葡萄糖乘积(TYG)指数、血小板参数及血清肌酸激酶同工酶(CK-MB)水平与急性ST段抬高型心肌梗死(STEMI)患者主要不良预后事件的关系。方法回顾性收集2021年2月—2022年2月成都市第三人民医院收治的205例STEMI患者临床资料,所有患者均展开为期12个月的随访,依据随访期间是否出现不良心血管事件(MACE)设为发生组(n=64)与未发生组(n=141),分析两组一般情况,并探讨TYG、血小板分布宽度(PDW)、平均血小板体积(MPV)及CK-MB与STEMI预后的相关性。结果通过单因素及多因素Logistic回归分析,结果显示糖尿病史、CK-MB、PDW、MPV、TYG指数及LVEF均为STEMI发生MACE的独立危险因素(P<0.05);绘制CK-MB、PDW、MPV及TYG指数对STEMI发生MACE的受试者工作特征(ROC)曲线,结果显示CK-MB、PDW、MPV及TYG指数预测MACE的预测价值分别为0.828、0.621、0.728及0.825。结论TYG指数、PDW、MPV及血清CK-MB水平与STEMI患者发生MACE独立相关,监测TYG指数、PDW、MPV及血清CK-MB水平对预测MACE的出现具有一定临床价值。Objective:To study the correlation of triglyceride-glucose(TYG)index,platelet parameters,serum creatine kinase isozyme(CK-MB)level and major adverse cardiovascular events(MACE)in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods A retrospective analysis was conducted on the 205 patients with STEMI who were admitted to the department of cardiology of the Third People's Hospital of Chengdu from February 2021 to February 2022.All patients were divided into two groups:the occurrence group(n=64)and the non-occurrence group(n=141)according to the presence or absence of MACE during 12 months follow-up.TYG index,platelet distribution width(PDW),mean platelet volume(MPV),CK-MB and the prognosis of STEMI were analyzed between two groups.Results Through univariate analysis and multivariate Logistic regression analysis,the results showed that diabetes history,CK-MB,PDW,MPV,TYG index and LVEF were independent risk factors for MACE in patients with STEMI(P<0.05).The receiver operating characteristic(ROC)curve analysis showed that the areas under the curves of CK-MB,PDW,MPV,and TYG index for predicting MACE were 0.828,0.621,0.728 and 0.825 respectively.Conclusion TyG index,PDW,MPV,and serum CK-MB level are correlated with the occurrence of MACE in patients with STEMI in this study.Assessing these measures would provide clinical benefits to patients with STEMI.

关 键 词：三酰甘油葡萄糖乘积指数 血小板参数 血清肌酸激酶同工酶 急性ST段抬高型心肌梗死 相关性 

分 类 号：R541[医药卫生—心血管疾病]