创伤后脓毒症早期预警诊断血浆生物标志物的研究进展  

Research progress on plasma biomarkers for early warning diagnosis of post-traumatic sepsis

作　　者：冯珂[1] 勾燚 吕博辉 张俊飞 马磊 FENG Ke;GOU Yi;LYU Bohui;ZHANG Junfei;MA Lei(Department of Emergency Medicine,General Hospital of Ningxia Medical University,Yinchuan Ningxia 750004,China)

机构地区：[1]宁夏医科大学总医院急诊科,宁夏银川750004 [2]宁夏医科大学第一临床医学院,宁夏银川750004

出　　处：《中国急救复苏与灾害医学杂志》2024年第6期830-834,837,共6页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：2022年宁夏回族自治区重点研发计划项目(编号:2022BEG02049);2023年宁夏自然科学基金重点项目(编号:2023AAC02068)。

摘　　要：创伤作为急诊科常见疾病之一,占全球疾病负担的10.1%,是我国45岁以下人群死亡的主要原因。创伤后脓毒症是组织损伤、休克、免疫功能紊乱、缺氧、应激等原因引起DAMPs及其他介质的释放,其发生率、病死率高,是创伤后期主要死亡原因,因此早期诊断、早期治疗则是改善创伤后脓毒症预后的重要前提。但是创伤后机体往往存在炎症反应综合征和器官功能障碍,容易掩盖创伤脓毒症的发生,给创伤脓毒症早期诊断、早期治疗带来了极大挑战。近10余年创伤后脓毒症早期诊断标志物的研究作为创伤医师、急诊外科医师、重症医师研究的重点之一,很多用于早期诊断的血浆生物标志物被发现,但仍缺乏统一的、公认的早期诊断生物标志物。此外依靠单一血浆生物标志物,难以做到精准预测创伤脓毒症的发生。该研究对创伤后脓毒症早期血浆诊断生物标志物进行综述,为创伤后脓毒症早期预警诊断提供思路。Trauma is one of the common diseases in emergency room.It accounts for 10.1%of the global disease burden andis the main cause of deathpeople under the age of 45 in China.Post-traumatic sepsis is the release of damage-associated molecular patterns molecules(DAMPs)and other mediators caused by tissue injury,shock,immune dysfunction,hypoxia,stress and other reasons.It has a high incidence and mortality rate and is the main cause of death in the late period of trauma.Therefore,early diagnosis and treatment is an importantprerequisite for improving the prognosis of post-traumatic sepsis.However,inflammatory response syndrome and organ dysfunction often exist in the body after trauma,which can easily mask the occurrence of trauma sepsis.In the past 10 years,the research on markers for early diagnosis of post-traumatic sepsis has been one of the focuses of research.There is a lack of unified and recognized biomarkers for early diagnosis.In addition,it is difficult to accurately predict the occurrence of trauma sepsis relying on a certain plasma biomarker.This study reviews early plasma diagnostic biomarkers for post-traumatic sepsis to provide ideas for early warning diagnosis of post-traumatic sepsis.

关 键 词：创伤后脓毒症 生物标志物 研究进展 

分 类 号：R641[医药卫生—外科学]