药物涂层球囊与药物洗脱支架治疗冠脉小血管狭窄伴轻度钙化的疗效及安全性比较  

Drug coated balloons and drug-eluting stents for the treatment of coronary small vessel stenosis with mild calcification comparison of efficacy and safety

作　　者：王月芳 WANG Yuefang(Haiyan County People's Hospital,Haiyan 314300,China)

机构地区：[1]海盐县人民医院,浙江海盐314300

出　　处：《浙江实用医学》2024年第1期6-9,45,共5页Zhejiang Practical Medicine

摘　　要：目的比较药物涂层球囊(DCB)与药物洗脱支架(DES)治疗冠脉小血管狭窄伴轻度钙化的疗效及安全性。方法选择2020年8月~2022年10月浙江省海盐县人民医院收治的冠脉小血管狭窄伴轻度钙化患者80例,随机分为支架组(药物洗脱支架治疗)和球囊组(药物涂层球囊治疗),每组40例。记录两组术前、术后和术后1年最小管腔直径、晚期管腔丢失和术后1年管腔直径净增长。统计两组术后1年内靶血管再狭窄率及心肌梗死、全因死亡、脑血管意外、靶血管重建等不良事件发生率。结果两组术前、术后以及术后1年最小管腔直径比较,差异均无统计学意义(P>0.05),但术后及术后1年与治疗前比较,最小管腔直径均有扩大(P<0.05);两组球囊组晚期管腔丢失、术后1年管腔直径净增长长度比较差异无统计学意义(P>0.05)。术后1年,两组靶血管再狭窄率(5.00%&7.50%)差异无统计学意义(χ^(2)=0.213,P=0.644)。术后6个月和1年,两组心肌梗死、全因死亡、脑血管意外、靶血管重建等不良事件发生率比较差异均无统计学意义(P>0.05)。结论药物涂层球囊用于冠脉小血管狭窄伴轻度钙化病变可达到与药物洗脱支架同样的疗效与安全性,在临床上可作为药物洗脱支架的替代治疗方案。Objective To compare the efficacy and safety of drug coated balloon(DCB)and drug eluting stent(DES)in the treatment of coronary small vessel stenosis with mild calcification.Method Eighty patients with coronary small vessel stenosis and mild calcification admitted to Haiyan County People's Hospital in Zhejiang Province from August 2020 to October 2022 were randomly divided into a stent group(drug-eluting stent treatment)and a balloon group(drug-coated balloon treatment),with 40 cases in each group.Record the minimum lumen diameter of two groups before surgery,after surgery,and 1 year after surgery,and calculate the late stage lumen loss and net increase in lumen diameter 1 year after surgery.Statistically analyze the rates of target vessel restenosis and adverse events such as myocardial infarction,all-cause mortality,cerebrovascular accidents,and target vessel reconstruction within one year after surgery in two groups.Results There was no statistically significant difference in the minimum lumen diameter between the two groups before,after,and 1 year after surgery(P>0.05).However,compared with before treatment,the minimum lumen diameter increased afer surgery and 1 year after surgery(P<0.05);There was no statistically significant difference(P>0.05)between the two balloon groups in terms of late stage luminal loss and net increase in luminal diameter at 1 year after surgery.After 1 year of surgery,there was no statistically significant difference in the rate of target vessel restenosis between the two groups(5.00%&7.50%)(χ^(2)=0.213,P=0.644).However,at 6 months and 1 year after surgery,there was no statistically significant dfference in the incidence of adverse events such as myocardial infarction,all-cause death,cerebrovascular accidents,and target vessel reconstruction between the two groups(P>0.05).Conclusion Drug coated balloons used for coronary small vessel stenosis with mild calcification can achieve the same efficacy and safety as drug-eluting stents,and can be used as an alternative treatment option for

关 键 词：冠脉小血管狭窄 轻度钙化 药物涂层球囊 药物洗脱支架 疗效 安全性 

分 类 号：R541.4[医药卫生—心血管疾病]