pH-时滞型新疆一枝蒿结肠定位片的制备及体外释放评价  

Preparation and Release Evaluation in Vitro of pH-time Lag Colon Specific Tablets from Artemisia Rupestris L.

作　　者：刘志强[1] 张钰琪 关志宇[1] 彭石根 谢毓敏 郭玉红 李梦淋 LIU Zhiqiang;ZHANG Yuqi;GUAN Zhiyu;PENG Shigen;XIE Yumin;GUO Yuhong;LI Menglin(Jiangxi University of Chinese Medicine,Nanchang 330004,China)

机构地区：[1]江西中医药大学,南昌330004

出　　处：《江西中医药大学学报》2024年第3期80-83,87,共5页Journal of Jiangxi University of Chinese Medicine

基　　金：江西省人社厅博士后科研项目(252591);江西中医药大学中药学一流学科科研项目(JXSYLXK-ZHYAO049);江西中医药大学校级科技创新团队发展计划项目(CXTD-22004)。

摘　　要：目的:制备pH-时滞型新疆一枝蒿结肠定位片并对其体外释放性能进行评价。方法:采用压制包衣、喷雾包衣的方法制备结肠定位片,以总黄酮累积释放度为指标,分别考察压制包衣时滞材料处方比例、包衣用量、上下层填料比例,pH控释层处方比例与包衣增重。结果:经过考察,最优工艺处方为EC-PEG 6 000(4∶1),压制包衣0.1 g,压制包衣上下层填料(1.5∶1),Eudragit FS 30 D-Eudragit L30 D-55(2∶1),p H控释层包衣增重为7%时,制得结肠定位制剂在0.1 mol/L HCl溶液中2 h内不释药,在pH 6.8磷酸盐缓冲液中4 h累积释放度<10%,在p H 7.5磷酸盐缓冲液中6 h累积释放度>80%。结论:经过筛选后的结肠定位片能够实现结肠定位释放的目的且体外释放稳定。Objective:To prepare pH-time lag colon specific tablets of Artemisia rupestris L.and evaluate release performance in vitro.Methods:Colon specific tablets were prepared by pressing coating and spray coating.The cumulative release of total flavonoids as the index,the prescription proportion of time lag materials for pressing coating,the amount of coating,the proportion of upper and lower fillers,the prescription proportion of pH controlled release layer and the coating weight gain were investigated respectively.Results:After inspection,the optimal technological formula was EC-PEG 6000(4∶1),0.1 g of pressing coating,upper and lower layers of pressing coating filler(1.5∶1),Eudragit FS 30 D-Eudragit L30 D-55(2∶1),and when the weight gain of pH controlled release layer coating was 7%,the colon specific preparation was not released in 0.1 mol/L HCl(2 h)solution,the cumulative release was less than 10%in pH 6.8 phosphate buffer solution(4 h),and the cumulative release in pH 7.5 phosphate buffer(6 h)was great than 80%.Conclusion:The colon specific tablets can achieve colon specific release and its release is stable in vitro.

关 键 词：新疆一枝蒿 pH-时滞型结肠定位片 压制包衣 累积释放度 

分 类 号：R284[医药卫生—中药学]