黑线姬鼠实验动物化研究进展  

Recent Advances of Apodemus agrarius as Laboratory Animal

作　　者：金志民[1] 李强[1] 鲁思含 孙悦 贾修歧 JIN Zhimin;LI Qiang;LU Sihan;SUN Yue;JIA Xiuqi(College of Life Science and Technology Mudanjiang Normal University,Mudanjiang,Heilongjiang 157011,China)

机构地区：[1]牡丹江师范学院,黑龙江牡丹江157011

出　　处：《天津农业科学》2024年第5期24-30,共7页Tianjin Agricultural Sciences

基　　金：国家重点研发项目(2023YFF0724600);黑龙江省2023年度省属高校基本科研业务费科研项目(MNUQN202305);生物学学科卓越研究生培养模式改革创新项目(MSYZYXM2022004);生物学学科研究生导学思政团队(KCSZTD-2022012);牡丹江师范学院青年学术骨干项目(MNUQN202305);牡丹江师范学院“揭榜挂帅”项目(kjcx2023-105mdjnu)。

摘　　要：自新冠肺炎疫情以来,全球以动物为媒介的传染病不断发生,人们需要更多种类的实验动物作为研究样本。黑线姬鼠(Apodemus agrarius)是一种我国常见的农田害鼠,繁殖期短、适应能力强,在我国分布广泛,是影响我国农业生产的主要害鼠之一。另外,黑线姬鼠也是汉坦病毒(Hantavirus)、莱姆病伯氏疏螺旋体(Borrelia burgdorferi)和刚地弓形虫(Toxoplasma gondii)的天然携带者,是流行病学研究的重要调查样本,同时在构建疾病模型和探究病原体致病机制方面也更具优势,其实验动物化的研究情况应该受到重视。本文总结了黑线姬鼠分类及其分布、繁殖学研究、生理学研究、分子生物学研究、携带病原体概况,并对黑线姬鼠的繁殖研究、多组学应用、病原探究和发展前景进行展望,以期为黑线姬鼠后续实验动物资源开发提供帮助。Since the COVID-19 outbreak,animal-mediated infectious diseases have been occurring around the world,and people need more species of experimental animals as research samples.Apodemus agrarius is a common farm rodent in China,with short breeding period and strong adaptability.It is widely distributed and is one of the main rodents affecting agricultural production in China.On the other hand,Apodemus agrarius is also a natural carrier of Hantavirus,Borrelia burgdorferi and Toxoplasma gondii,which is an important investigative sample in epidemiological studies,as well as being more advantageous in constructing disease models and probing the pathogenic mechanisms of pathogens,the research situation of its experimental animalization should be valued.The article summarized the classification and distribution,reproduction,physiology,molecular biology and the general situation of carrying pathogend.The reproduction studies,multi-omics applications,pathogen exploration and development prospects of the Apodemus agrarius were discussed and outlooked,with a view to providing assistance for the subsequent development of experimental animal resources of the blackline guinea pig.

关 键 词：黑线姬鼠 实验动物 繁殖 携带病原 

分 类 号：Q95-33[生物学—动物学]