甲状旁腺功能减退症-妊娠哺乳期-血钙波动  

Hypoparathyroidism-pregnancy and lactation periods-serum calcium fluctuation

作　　者：王佳佳 王鸥 宋桉 姜艳 李梅 夏维波 邢小平 WANG Jia-jia;WANG Ou;SONG An;JIANG Yan;LI Mei;XIA Wei-bo;XING Xiao-ping(Department of Endocrinology,Key Laboratory of Endocrinology,National Health Commission,Peking Union Medical College Hospital,Chinese Academy of Medical Science&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院、北京协和医学院、北京协和医院内分泌科、国家卫生健康委员会内分泌重点实验室,北京100730

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2024年第2期131-136,共6页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：国家自然科学基金面上项目(81873641,82070817)。

摘　　要：本文报告一例甲状旁腺功能减退症病例,患者平素病情稳定,妊娠哺乳期血钙出现较大波动。妊娠期血钙下降、尿钙排泄增加,需增加药量。哺乳期血钙增加,出现高钙血症,需停用活性维生素D;至哺乳17个月时药物剂量仍低于孕前水平。本文对妊娠哺乳期母体钙稳态的生理变化进行总结,并对甲状旁腺功能减退症患者妊娠哺乳期的钙稳态变化及相关机制进行文献复习。This article reports a case of hypoparathyroidism,who showed stable calcium homeostasis before pregnancy whereas unstable serum calcium during pregnancy and lactation periods.During pregnancy,the serum calcium decreased while urinary calcium excretion increased,and drug dosage was increased.During lactation,the serum calcium increased,and the patient developed hypercalcemia.Active vitamin D was stopped.Drug dosage was less than pre-pregnancy until the 17th month of lactation.The article summarizes physiological change of calcium homeostasis during pregnancy and lactation periods in hypoparathyroidism patients and its related mechanisms.

关 键 词：甲状旁腺功能减退症 妊娠期 哺乳期 血钙 尿钙 

分 类 号：R681[医药卫生—骨科学]