2019-2022年开封市健康人群麻疹、风疹和流行性腮腺炎抗体水平监测分析  

Monitoring and Analysis of Measles,Rubella and Mumps Antibody Levels in Healthy Population in Kai⁃feng City from 2019 to 2022

作　　者：王雪[1] 胡淮洁[1] 韩佳欣 王坤 Wang Xue;Hu Huaijie;Han Jiaxin;Wang Kun(Laboratory Department of Kaifeng Center for Disease Control and Prevention,Kaifeng Henan 475004)

机构地区：[1]开封市疾病预防控制中心检验科,河南开封475004

出　　处：《口岸卫生控制》2024年第3期20-23,28,共5页Port Health Control

摘　　要：目的了解开封市健康人群麻疹、风疹、流行性腮腺炎抗体水平,评价疫苗免疫效果,为科学防控及相关疾病传播风险评估提供依据。方法采用多阶段分层抽样的方法采集开封市4个监测点0~79岁共计1983名健康人群血清标本,利用ELISA方法分别对血清中麻疹、风疹、流行性腮腺炎IgG抗体进行检测。结果1983份血清样本中,麻疹、风疹、腮腺炎的抗体阳性率分别为90.97%、83.16%、90.42%。不同性别间麻疹、风疹、流行性腮腺炎抗体阳性率没有显著性差异(P>0.05)。不同年龄组、不同监测点间的抗体阳性率具有显著性差异(P<0.01)。不同免疫史及距末次疫苗接种不同时间的麻疹、风疹抗体阳性率具有显著性差异(P<0.01),流行性腮腺炎抗体阳性率无显著性差异(P>0.05),但3种抗体阳性率均随免疫剂次的增加而升高。结论开封市存在麻疹、风疹、流行性腮腺炎免疫规划薄弱环节,应关注8月龄幼儿首剂疫苗的及时接种,对育龄期妇女进行宣传教育,及时开展抗体水平监测,积极开展查漏补种工作。Objective To investigate the antibody levels of measles,rubella and mumps in the healthy population of Kaifeng City,evaluate the effect of vaccine immunization,and provide a basis for scientific prevention and control and risk assessment of the transmission of related diseases.Methods A total of 1983 serum specimens of healthy people aged 0-79 years were collected from four monitoring sites in Kaifeng City by multi-stage stratified sampling,and IgG antibodies to measles,rubella,and mumps were detected in serum by ELISA method respectively.Re-sults Among the 1983 serum samples,the antibody positive rates of measles,rubella and mumps were 90.97%,83.16%and 90.42%,respectively.There was no significant difference in the antibody positive rate of measles,ru-bella,and mumps between different genders(P>0.05).Antibody positive rates between different age groups and dif-ferent monitoring sites were significantly different(P<0.01).Antibody positive rates for measles and rubella with different immunization histories and different times from the last vaccination had significant differences(P<0.01),and antibody positive rates for mumps did not have significant differences(P>0.05),but the three antibody positive rates increased with the increase in the number of immunization doses.Conclusion Weaknesses in immunization planning for measles,rubella and mumps exist in Kaifeng City,and attention should be paid to the timely vaccina-tion of the first dose of vaccine for young children at 8 months of age,publicity and education for women of child-bearing age,timely monitoring of antibody levels,and active efforts to check for omissions and make up for vaccina-tion.

关 键 词：麻疹 风疹 流行性腮腺炎 抗体水平 

分 类 号：R511[医药卫生—内科学]