基于“三焦气化-营卫”体系探析中医药调节肿瘤免疫作用机制  

Regulation of traditional Chinese medicine on tumor immunity based on the system of“Qi trans⁃formation of triple energizers-nutritive and defensive Qi”

作　　者：徐陆凡 张哲 罗毅[3] Xu Lufan;Zhang Zhe;Luo Yi(The Third School of Clinical Medicine,Nanjing University of Chinese Medicine,Nanjing Jiangsu 210028;Nanjing Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing Jiangsu 210012;Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing Jiangsu 210028)

机构地区：[1]南京中医药大学第三临床医学院,江苏南京210028 [2]南京中医药大学附属南京中医院,江苏南京210012 [3]南京中医药大学附属中西医结合医院,江苏南京210028

出　　处：《山西中医药大学学报》2024年第3期332-336,348,共6页Journal of Shanxi University of Chinese Medicine

基　　金：江苏省卫健委高层次卫生人才“六个一工程”拔尖人才项目(LGY2020003);南京中医药大学自然基金项目(XZR2021029)。

摘　　要：肿瘤免疫发挥着杀伤肿瘤细胞、保护机体的作用,免疫检查点抑制剂(ICIs)的广泛应用打开了肿瘤治疗的新格局,但也存在单药疗效有限、联合用药安全性等问题。以“三焦气化-营卫”体系为基础,探讨中医药调节肿瘤免疫增效的可能。从三焦气化这一宏观的角度出发,探讨现代肿瘤免疫的中医理解,剖析营卫与现代免疫及肿瘤免疫的联系,结合癌症发生发展中的痰浊瘀血等病理因素,探索中医药调节肿瘤免疫治疗之法。通过促使三焦气化如常,发挥“解毒散结,营卫互用”免疫主体作用,运用益气活血、祛瘀通路、温阳化痰,使一身之气顺和,达到正复邪去之效。Tumor immunity plays a role in killing tumor cells and protecting the body.The wide application of immune checkpoint inhibitors(ICIs)has opened up a new pattern of tumor therapy,but there are also problems such as limited efficacy of single drug and safety of combined drugs.Based on the system of“Qi transformation of triple energizers-nutritive and defensive Qi”,the possibility of regulating tumor immunity and enhancing effect of traditional Chinese medicine is discussed.In this paper,we discuss the understanding of modern tumor immunity in TCM from the macroscopic perspective of Qi transformation of triple energizers,analyze the relationship between nutritive and defensive Qi,modern immunity and tumor immunity,and explore the TCM regulating tumor immunotherapy in combination with pathological factors such as phlegm turbidity and blood stasis in the occurrence and development of cancer.By promoting the normal Qi transformation of triple energizers to play the roles of immune function of detoxicating and resolving a mass and interaction between nutritive and defensive Qi and using the methods of supplementing Qi and activating blood circulation,removing stasis and dredging collaterals,and warming Yang and eliminating phlegm,the Qi of whole body will be smooth,so as to achieve the effect of restoring the healthy Qi and eliminating the pathogenic factors.

关 键 词：肿瘤 三焦 三焦气化 营卫 免疫治疗 中医药疗法 

分 类 号：R273[医药卫生—中西医结合]