硫氧还蛋白-1在脑缺血中作用的研究现状  

Research status of research on the role of thioredoxin 1 in cerebral ischemia

作　　者：刘怀玉 王可 闫文静 王月[1,2] 张文欣 何治[1,2,3] LIU Huai-yu;WANG Ke;YAN Wen-jing;ANG Yue;ZHANG Wen-xin;HE Zhi(Third-grade Pharmacological Laboratory on Traditional Chinese Medicine,State Administration of Traditional Chinese Medicine,China Three Gorges University,Yichang 443002,Hubei Province,China;School of Health Medicine,China Three Gorges University,Yichang 443002,Hubei Province,China;School of Medicine,Jiaxing University,Jiaxing 314001,Zhejiang Province,China)

机构地区：[1]三峡大学国家中医药管理局中药药理科研三级实验室,湖北宜昌443002 [2]三峡大学健康医学院,湖北宜昌443002 [3]嘉兴大学医学院,浙江嘉兴314001

出　　处：《中国临床药理学杂志》2024年第10期1525-1529,共5页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金面上基金资助项目(82204837);国家自然科学基金青年科学基金资助项目(82073824);浙江省自然科学基金资助项目(LQ23H290004)。

摘　　要：硫氧还蛋白-1(Trx-1)是一种小分子氧化还原蛋白,通常存在于哺乳动物细胞中,通过提供电子或调节相关蛋白来响应不断变化的氧化还原环境。根据现有证据该文将简要介绍Trx-1的基本概念以及Trx-1在脑缺血中的表达变化,重点介绍Trx-1在脑缺血发生后的神经保护作用,包括抗氧化、抗炎、抗凋亡、促进细胞生长、血管再生作用,以及其在脑缺血相关疾病中的作用。Thioredoxin-1(Trx-1)is a petite redox protein primarily encountered in mammalian cells.It responds to alterations in the redox environment by facilitating electron transfer and regulating associated proteins.This paper provides a concise overview of Trx-1,focusing on its altered expression patterns during cerebral ischemia.The emphasis is on its neuroprotectiveattributes followingcerebralischemia,encompassing anti-oxidation,anti-inflammation,anti-apoptosis,promotion of cell growth,angiogenesis,and its involvement in cerebral ischemia-related pathologies.

关 键 词：硫氧还蛋白-1 脑缺血 硫氧还蛋白相互作用蛋白 神经保护 作用机制 

分 类 号：R972[医药卫生—药品]