心房颤动患者肾功能恶化的危险因素研究进展  

Risk factors for renal function deterioration in atrial fibrillation patients:a research review

作　　者：蓝子尹 郭军[1] LAN Ziyin;GUO Jun(Department of Cardiology,the First Affiliated Hospital of Jinan University,Guangzhou Guangdong 510630,China)

机构地区：[1]暨南大学附属第一医院心内科,广东广州510630

出　　处：《实用心电学杂志》2024年第3期320-324,共5页Journal of Practical Electrocardiology

基　　金：广州市科技计划重点研发项目(202103000010);暨南大学附属第一医院临床前沿新技术项目(JNU1AF-CFTP-2022-a01218)。

摘　　要：心房颤动(简称房颤)是临床常见的心律失常。肾功能损害为房颤患者常见的伴发疾病,会增加患者脑卒中、血栓栓塞以及出血的风险。然而,目前对于房颤患者肾功能恶化的病理生理机制仍未阐明。早期识别肾功能恶化的高危因素并采取干预措施,可能会降低房颤患者肾功能恶化的发生率。本文结合最新的研究进展,从二尖瓣舒张早期血流峰值速度与整体舒张期应变率比值、左心房内径、踝臂指数、CHA_(2)DS_(2)-VASc评分以及抗凝药物使用对房颤患者肾功能恶化的影响等方面进行综述。Atrial fibrillation(AF)is a type of common arrhythmia in clinical practice.Renal dysfunction is a commonly concomitant disease in AF patients which increases their risk of stroke,thromboembolism,and bleeding.However,the current understanding of the pathophysiological mechanisms underlying renal function deterioration in AF patients remains incomplete.The early identification of high-risk factors for renal function deterioration and the implementation of intervention measures may contribute to a reduced incidence of renal function decline in patients with AF.This article reviews the latest research progress,focusing on the impact of early diastolic blood peak flow velocity of the mitral valve to global diastolic strain rate ratio,left atrial diameter,ankle-brachial index,CHA_(2)DS_(2)-VASc score,and use of anticoagulant drugs on renal function deterioration in patients with AF.

关 键 词：心房颤动 肾功能 左心房内径 踝臂指数 CHA2DS2-VASc评分 

分 类 号：R541.75[医药卫生—心血管疾病]