滋肾活血方治疗肾虚血瘀型卵巢储备功能减退疗效分析  

Analysis of curative effect of Zishen Huoxue Decoction in treating kidney deficiency and blood stasis type of diminished ovarian reserve

作　　者：孙淑云[1] 殷一红[1] 叶利群[1] SUN Shuyun;YIN Yihong;YE Liqun(Department II of Gynecology,Ningbo Municipal Hospital of Traditional Chinese Medicine(TCM),Affiliated Hospital of Zhejiang Chinese Medical University,Ningbo,Zhejiang 315010,China)

机构地区：[1]浙江中医药大学附属宁波市中医院妇二科,浙江宁波315010

出　　处：《中华全科医学》2024年第6期975-978,1084,共5页Chinese Journal of General Practice

基　　金：国家中医药管理局科技司-浙江省中医药管理局共建科技计划项目(GZY-ZJ-KJ-23090);宁波市科技计划项目(2022J285)。

摘　　要：目的观察分析滋肾活血方治疗肾虚血瘀型卵巢储备功能减退的临床疗效,及对卵巢功能和血流的影响,为临床治疗提供依据。方法选取2022年7月—2023年11月宁波市中医院收治的750例卵巢储备功能减退(肾虚血瘀型)患者作为研究对象,采用随机数字表法将患者分为A组(滋肾活血方治疗),B组(戊酸雌二醇片联合地屈孕酮片治疗),C组(滋肾活血方+戊酸雌二醇片联合地屈孕酮片治疗),每组250例。比较3组患者治疗效果、治疗前后血清促卵泡刺激素(FSH)、黄体生成素(LH)、抗米勒管激素(AMH),窦卵泡数量(AFC)、卵巢体积(OV)以及卵巢基质血流指数的变化。结果A组、B组、C组总有效率分别为82.0%(205/250)、64.4%(161/250)、90.8%(227/250),C组总有效率均高于B组、A组,A组总有效率高于B组(P<0.05)。治疗后C组FSH、LH较A组及B组显著下降,A组FSH、LH较B组显著下降(P<0.05);C组AMH较A组及B组显著上升,A组AMH较B组显著上升(P<0.05)。治疗后C组AFC、OV较A组及B组显著上升,A组AFC、OV较B组显著上升(P<0.05)。治疗后C组PSV、VI、FI较A组及B组显著上升,A组VI较B组显著上升(P<0.05)。结论滋肾活血方治疗肾虚血瘀型卵巢储备功能减退患者能有效调节卵巢功能,改善患者卵巢血流灌注,临床疗效显著,值得临床应用。Objective To observe and analyze the clinical efficacy of Zishen Huoxue Decoction in treating kidney deficiency and blood stasis type of diminished ovarian reserve,and its effect on ovarian function and ovarian blood flow,providing a basis for clinical treatment.Methods A total of 750 patients with diminished ovarian reserve(kidney deficiency and blood stasis type)admitted to Ningbo Municipal Hospital of Traditional Chinese Medicine(TCM)from July 2022 to November 2023 were selected as the study subjects,and the included patients were divided into group A(treated with Zishen Huoxue Decoction),group B(treated with estradiol valerate tablets combined with dydrogesterone tablets),and group C(treated with Zishen Huoxue Decoction+estradiol valerate tablets combined with dydrogesterone tablets)using the random number table method,with 250 patients in each group.Treatment effects,changes in follicle-stimulating hormone(FSH),luteinizing hormone(LH),anti-Müllerian hormone(AMH),antral follicle count(AFC),ovarian volume(OV),and ovarian stromal flow index before and after treatment were compared among the three groups of patients.Results The total effective rates of group A,group B,and group C were 82.0%(205/250),64.4%(161/250),and 90.8%(227/250),respectively,and the total effective rates of group C were all higher than those of group B and A,and the total effective rate of group A was higher than that of group B(P<0.05).After treatment,FSH and LH decreased more significantly in group C than in groups A and B,and FSH and LH decreased more significantly in group A than in group B(P<0.05).AMH rose more significantly in group C than in groups A and B,and AMH rose more significantly in group A than in group B(P<0.05).AFC and OV rose more significantly in group C than in groups A and B after treatment,and AFC and OV rose more significantly in group A than in group B(P<0.05).PSV,VI,and FI rose were more significantly in group C than in groups A and B after treatment,and VI levels rose was more significantly in group A than in grou

关 键 词：卵巢储备功能减退 肾虚血瘀 滋肾活血方 卵巢血流 

分 类 号：R711.75[医药卫生—妇产科学] R271.1[医药卫生—临床医学]