清肺化痰汤对痰热阻肺证支气管扩张症急性期患者气道黏液高分泌的影响  

Effect of Qingfei Huatan Decoction on airway mucus hypersecretion in patients with Acute Exacerbation of Bronchiectasis with Phlegm-heat Obstructive Pulmonary Syndrome

作　　者：杨红梅[1,2] 玉结珍[3] 赵清鸿 潘玲 罗美群[2] 梁炜[2] 李瑞祥[2] 陈斯宁[2] YANG Hong-mei;YU Jie-zhen;ZHAO Qing-hong;PAN Ling;LUO Mei-qun;LIANG Wei;LI Rui-xiang;CHEN Si-ning(Applicant for Doctoral Degree with an Equivalent Educational Level in Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Ruikang Hospital Afiliated to Guangxi University of Chinese Medicine,Nanning 530011,China;Guangxi University of Chinese Medicine,Nanning 530000,China)

机构地区：[1]广州中医药大学同等学力申请博士学位人员,广东广州510405 [2]广西中医药大学附属瑞康医院,广西南宁530011 [3]广西中医药大学,广西南宁530000

出　　处：《时珍国医国药》2024年第3期666-668,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(81760853);广西壮族自治区中青年教师基础能力提升项目(2019KY0343)。

摘　　要：目的观察清肺化痰汤对痰热阻肺证支气管扩张症急性期患者气道黏液高分泌的影响。方法60例符合条件患者采取软件生成随机数字表法分治疗组、对照组各30例。对照组患者仅常规西医治疗,治疗组在常规西医治疗基础加服清肺化痰汤,疗程10日。比较两组中医证候疗效,咳嗽症状总积分,24h痰量,痰黏蛋白5AC(MUC5AC)和中性粒细胞弹性蛋白酶(NE)含量,血炎症因子白细胞介素-6(IL-6)、C反应蛋白(CRP)和降钙素原(PCT)水平以及不良反应情况。结果治疗后,治疗组的总有效率93.33%,高于对照组的总有效率80.00%(P<0.05);两组咳嗽症状总积分、24h痰量、痰MUC5AC和NE,及血清炎症因子IL-6、CRP、PCT都较治疗前下降,且治疗组更优于对照组(P<0.05);治疗期间两组各有2例轻微的消化道不良反应,差异无统计学意义。结论清肺化痰汤协同治疗痰热阻肺证支气管扩张症急性期患者能进一步降调气道黏液高分泌及血清炎症因子水平,因此显著改善咳嗽、咳痰症状,临床疗效更优。Objective To observe the effect of Qingfei Huatan Decoction on airway mucus hypersecretion in patients with acute exacerbation of bronchiectasis with phlegm-heat obstructive pulmonary syndrome. Methods A total of 60 eligible patients were randomly divided into treatment group and control group through random number table by software, with 30 cases in each group. The patients in control group were only treated with conventional western medicine, while the patients in treatment group was additionally treated with Qingfei Huatan Decoction on the basis of control group. The treatment was ten days in both groups. Curative effect of traditional Chinese medicine syndrome, cough symptom score, the amount of sputum in 24 hours, the levels of mucin5AC(MUC5AC) and neutrophil elastase(NE) in sputum, the levels of inflammatory factors in blood including interleukin-6(IL-6), C reactive protein(CRP),Procalcitonin(PCT) and adverse drug reactions were evaluated and compared between two groups. Results After treatment, the total effective rate was 93.33% in treatment group, higher than 80.00% in control group(P<0.05). As compared with the levels before treatment, cough symptom score, the amount of sputum in 24 hours, the levels of MUC5AC and NE in sputum, the levels of inflammatory factors in blood including IL-6, CRP, PCT were decreased after treatment in both groups, and the decrease in treatment group was more significant(P<0.05). Only 2 cases of mild digestive tract adverse reactions occurred in each group. There was no statistically significant difference.Conclusion Qingfei Huatan Decoction combined with conventional western medicine for patients with acute exacerbation of bronchiectasis with phlegm-heat obstructive pulmonary syndrome can further reduce the levels of airway mucus hypersecretion and inflammatory factors, and the symptoms of cough and sputum were significantly improved, therefore the clinical efficacy is better.

关 键 词：清肺化痰汤 支气管扩张症 痰热阻肺证 黏液高分泌 随机对照临床试验 

分 类 号：R256.1[医药卫生—中医内科学]