磁共振成像多模态参数联合miR-21、lncRNA FER1L4鉴别HCC与FNH的价值  

Value of magnetic resonance imaging multimodal parameters combined with miR-21 and lncRNA FER1L4 in distinguishing hepatocellular carcinoma from focal nodular hyperplasia

作　　者：常充阳 申放 Chang Congyang;Shen Fang(Department of Imaging,Yulin First Hospital,Yulin 718000,China;Department of Imaging,Shaanxi Rehabilitation Hospital for Disable Solders,Huayin 714200,China)

机构地区：[1]榆林市第一医院影像科,榆林718000 [2]陕西省荣誉军人康复医院影像科,华阴714200

出　　处：《国际医药卫生导报》2024年第11期1849-1853,共5页International Medicine and Health Guidance News

基　　金：陕西省重点研发计划(2020SF-061)。

摘　　要：目的探讨磁共振成像(magnetic resonance imaging,MRI)多模态参数联合微RNA-21(microRNA-21,miR-21)和长链非编码RNA(long non-coding RNA,lncRNA)FER1L4在鉴别肝细胞癌(hepatocellular carcinoma,HCC)与局灶性结节增生(focal nodular hyperplasia,FNH)中的有效性和精度。方法选取2014年1月至2022年12月榆林市第一医院收治的78例患者为研究对象,其中HCC 50例,男29例,女21例,年龄(59.03±13.12)岁,病程(2.12±1.43)年;FNH 28例,男16例,女12例,年龄(31.48±9.29)岁,病程(2.27±1.39)年。比较两组MRI多模态参数[持续性强化、快进快出、信号强度(signal intensity,SI)增强率、标准化表观扩散系数(standardized apparent diffusion coefficient,SIADC)、瘤周低信号环、对比剂充盈缺损、线状低信号分隔和中央星状瘢痕]以及病变组织中miR-21和lncRNA FER1L4水平。采用受试者操作特征曲线(receiver operating characteristic curve,ROC)评估MRI、miR-21和lncRNA FER1L4的诊断效能。采用t检验、χ^(2)检验。结果两组强化方式、SI增强率差异均无统计学意义(χ^(2)=3.640,t=0.207,均P>0.05),但是FNH组SIADC高于HCC组(t=7.906,P<0.05);两组肝胆期形态学特征(瘤周低信号环、对比剂充盈缺损、线状低信号分隔和中央星状瘢痕)比较,差异均有统计学意义(χ^(2)=17.160、17.814、21.840、13.868,均P<0.05)。HCC组织中miR-21表达水平高于FNH组织,而FER1L4表达水平低于FNH组织(均P<0.05)。当MRI、miR-21和lncRNA FER1L4三者联合时,诊断出HCC 49例,FHN 27例,曲线下面积0.972,灵敏度和特异度分别为98.0%和96.4%,约登指数0.944。结论MRI多模态参数联合病变组织中miR-21和lncRNA FER1L4水平可有效区分HCC和FNH。Objective To explore the effectiveness and accuracy of magnetic resonance imaging(MRI)multimodal parameters combined with microRNA-21(miR-21)and long non-coding RNA(lncRNA)FER1L4 in differentiating hepatocellular carcinoma(HCC)from focal nodular hyperplasia(FNH).Methods Seventy-eight patients treated at Yulin First Hospital from January 2014 to December 2022 were selected as the study objects,including 50 cases of HCC and 28 cases of FNH.There were 29 males and 21 females in the HCC group;they were(59.03±13.12)years old,with a disease course of(2.12±1.43)years.There were 16 males and 12 females in the FNH group;they were(31.48±9.29)years old,with a disease course of(2.27±1.39)years.The MRI multimodal parameters[persistent enhancement,rapid in and out,signal intensity(SI)enhancementratio,standardized apparent diffusion coefficient(SIADC),peritumoral low signal halo,contrast filling defect,linear low signal separation,and central stellate scar]and levels of miR-21 and lncRNA FER1L4 in the lesion tissues were compared between the two groups.The diagnostic efficacies of MRI,miR-21,and lncRNA FER1L4 were assessed by the receiver operating characteristic curves(ROC).t and χ^(2) tests were used.Results There were no statistical differences in the enhancement patterns and SIenhancementrate between the two groups(χ^(2)=3.640;t=0.207;both P>0.05).However,the SIADC in the FNH group was higher than that in the HCC group(t=7.906;P<0.05).There were statistical differences in the morphological features(peritumoral low signal halo,contrast filling defect,linear low signal separation,and central stellate scar)during the hepatobiliary phase between the two groups(χ^(2)=17.160,17.814,21.840,and 13.868;all P<0.05).The miR-21 expression in the HCC tissue was higher than that in the FNH tissue,whereas the FER1L4 expression in the HCC tissue was lower than that in the FNH tissue(both P<0.05).When combining MRI,miR-21,and lncRNA FER1L4,49 cases of HCC and 27 cases of FHN were correctly identified,with an area under the curve(AUC)

关 键 词：磁共振成像 肝细胞癌 局灶性结节增生 MIR-21 FER1L4 

分 类 号：R445.2[医药卫生—影像医学与核医学] R735.7[医药卫生—诊断学]