温针灸联合丙酸氟替卡松鼻喷雾剂在变应性鼻炎中的应用  

Effect of warm needle acupuncture and fluticasone propionate nasal spray on allergic rhinitis

作　　者：孙敦坡 王益松 Sun Dunpo;Wang Yisong(Department of Acupuncture and Moxibustion,Lianyungang Affiliated Hospital of Nanjing University of Chinese Medicine,Lianyungang 222004,China;Clinical Lab,Lianyungang Affiliated Hospital of Nanjing University of Chinese Medicine,Lianyungang 222004,China)

机构地区：[1]南京中医药大学连云港附属医院针灸科,连云港222004 [2]南京中医药大学连云港附属医院检验科,连云港222004

出　　处：《国际医药卫生导报》2024年第12期2015-2020,共6页International Medicine and Health Guidance News

基　　金：江苏省中医药管理局科技项目(YB2020073);江苏省科技厅高层次人才计划资助项目(2019-30345);连云港市医学重点人才资助项目(连卫科教2022-2号)。

摘　　要：目的探讨温针灸联合丙酸氟替卡松鼻喷雾剂对变应性鼻炎患者免疫功能和睡眠质量的影响。方法选取2021年5月至2023年10月在南京中医药大学连云港附属医院针灸科门诊及耳鼻喉科门诊接受治疗的变应性鼻炎患者462例为研究对象,采用随机数字表法将所有患者分为3组,各154例。温针组男85例,女69例;年龄(33.56±4.15)岁;病程(2.35±0.73)年;采用温针灸治疗。药物组男87例,女67例;年龄(34.02±4.34)岁;病程(2.37±0.54)年;采用丙酸氟替卡松鼻喷雾剂治疗。针药结合组男80例,女74例;年龄(33.89±4.26)岁;病程(2.41±0.76)年;采用温针灸联合丙酸氟替卡松鼻喷雾剂治疗。3组患者均治疗1个月。比较3组患者的临床疗效以及治疗前和治疗后的炎症指标、免疫功能指标水平;检测治疗前和治疗后的鼻腔阻力、鼻腔通气面积以及纤毛运动速率;通过匹兹堡睡眠质量指数(PSQI)和鼻炎生活质量问卷(RQLQ)评估患者的睡眠状况和生活质量;记录患者不良反应发生情况。采用方差分析、配对样本t检验和χ^(2)检验。结果治疗后,针药结合组的治疗总有效率[96.10%(148/154)]高于温针组[83.77%(129/154)]和药物组[81.82%(126/154)](均P<0.05);针药结合组的炎症指标和鼻腔阻力均低于温针组和药物组,免疫功能指标水平、鼻腔通气面积以及纤毛运动速率均优于温针组和药物组(均P<0.05);针药结合组PSQI评分[(6.42±1.02)分]和RQLQ评分[(39.52±5.03)分]均低于温针组[(9.30±1.52)分、(53.48±6.35)分]和药物组[(9.35±1.48)分、(54.36±6.42)分](均P<0.05);药物组的不良反应总发生率[14.29%(22/154)]高于温针组[2.60%(4/154)]和针药结合组[4.55%(7/154)](均P<0.05)。结论温针灸联合丙酸氟替卡松鼻喷雾剂治疗能提高变应性鼻炎患者的治疗效果,改善其免疫功能和睡眠质量。Objective To investigate the impact of integrating warm needle acupuncture with fluticasone propionate nasal spray on the immune function and sleep quality in individuals experiencing allergic rhinitis.Methods A total of 462 patients with allergic rhinitis who received treatment in the outpatient department of acupuncture and moxibustion and the outpatient department of otolaryngology in Lianyungang Affiliated Hospital of Nanjing University of Chinese Medicine from May 2021 to October 2023 were selected as the study objects,and were divided into 3 groups with 154 cases in each group by the random number table method.There were 85 males and 69 females in the heated needle group,the age was(33.56±4.15)years old,and the course of disease was(2.35±0.73)years.There were 87 males and 67 females in the medication group,the age was(34.02±4.34)years old,and the course of disease was(2.37±0.54)years.There were 80 males and 74 females in the combined therapy group,the age was(33.89±4.26)years old,and the course of disease was(2.41±0.76)years.The heated needle group received warm needle acupuncture treatment,the medication group was given fluticasone propionate nasal spray,and the combined therapy group received both warm needle acupuncture and fluticasone propionate nasal spray treatment for one month.The clinical efficacies of the three groups were compared,along with inflammation markers and immune function before and after treatment.The nasal resistance,nasal ventilation area,and ciliary movement rate were measured before and after treatment.The sleep status and quality of life were assessed by the Pittsburgh Sleep Quality Index(PSQI)and Rhinitis Quality of Life Questionnaire(RQLQ).The occurrence of adverse reactions in patients was recorded.Analysis of variance,paired t test,andχ^(2) test were used.Results After treatment,the total effective rate of the combined therapy group[96.10%(148/154)]was higher than those of the heated needle group[83.77%(129/154)]and the medication group[81.82%(126/154)](all P<0.05).The

关 键 词：变应性鼻炎 丙酸氟替卡松鼻喷雾剂 温针灸 免疫功能 睡眠质量 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]