一种高精度的非侵入式脑组织氧监测系统  

A high-precision non-invasive cerebral tissue oxygen monitoring system

作　　者：徐成喜 郭新茹 向婷 Xu Chengxi;Guo Xinru;Xiang Ting(Chengteng Medical Device(Shanghai)Co.,Ltd,Shanghai 200062,China;Kaonter Medical Technology Co.,Ltd,Suzhou,215300,China;Department of Biomedical Sciences,City University of Hong Kong,Hong Kong 999077,China)

机构地区：[1]晨腾医疗设备(上海)有限公司,上海200062 [2]苏州健通医疗科技有限公司,苏州215300 [3]香港城市大学生物医学工程系,中国香港999077

出　　处：《现代仪器与医疗》2024年第2期34-41,共8页Modern Instruments & Medical Treatment

摘　　要：目的本研究旨在介绍一种集成功能性近红外光谱(functional Near-Infrared Spectroscopy,fNIRS)与USB接口的非侵入式脑组织氧监测系统,提升监测实时性和操作便利性。方法本研究利用改良的比尔-朗伯特定律(Modified Beer-Lambert Law,MBLL)测定头皮下组织氧合变化,采用硅光电倍增器(Silicon Photomultipliers,SiPM)作为探测器,通过整合fNIRS和便携的USB接口,开发一款轻便、易于使用且成本效益高的脑血氧监测设备。本研究通过一系列详尽的试验验证脑组织氧检测系统的准确性、稳定性、可靠性、易用性和实用性。结果系统在与商业产品NeurOs Cerebral Oximetry比较中显示出±10%的准确性范围内。重复性测试表现出0.42%到3.93%的复现性误差,并在8h连续监测中表现稳定。结论本系统的精确性和稳定性为脑组织氧合水平的实时监测提供了可靠工具。未来研究将探索系统的小型化、可穿戴化以及人工智能技术集成。Objective This study presents a non-invasive cerebral tissue oxygen monitoring system integrating Functional Near-Infrared Spectroscopy(fNIRS)with USB interface,aimed at enhancing real-time monitoring capabilities and ease of operation.Methods In this study,Modified Beer-Lambert Law(MBLL)was used to measure tissue oxygenation changes under scalp and Silicon Photomultipliers(SiPM)was used as detector.By integrating fNIRS and portable USB interface,a lightweight,easy-to-use and cost-effective cerebral blood oxygen monitoring device has been developed.The accuracy,stability,reliability,ease of use and practicability of the brain tissue oxygen detection system were verified by a series of detailed experiments.Results Compared with the commercial product NeurOs Cerebral Oximetry,the system demonstrated accuracy within a±10%range.Reproducibility tests showed an error margin between 0.42%and 3.93%,with stable performance during 8 hours of continuous multi-channel monitoring.Conclusion The system's accuracy and stability provide a reliable tool for real-time monitoring of cerebral tissue oxygenation levels.Future research will explore miniaturization,wearability,and the integration of artificial intelligence technologies.

关 键 词：脑组织氧测量 USB接口 功能性近红外光谱技术 非侵入式监测 脑血氧参数 

分 类 号：R197.39[医药卫生—卫生事业管理] O439[医药卫生—公共卫生与预防医学] TH77[机械工程—光学工程]