1例接种新型冠状病毒灭活疫苗偶合两种病原体感染调查  

Investigation of one case of two pathogen infections coupled to the inactivated SARS-CoV-2 vaccination

作　　者：冯国跃 马敬仓[1] 沙娜 刘景顺[1] 陶泽新[3] 徐凌忠[4] FENG Guoyue;MA Jingcang;SHA Na;LIU Jingshun;TAO Zexin;XU Lingzhong(Heze Center for Disease Control and Prevention,Heze,Shandong 274010,China;不详)

机构地区：[1]菏泽市疾病预防控制中心,山东菏泽274010 [2]济宁市第一人民医院 [3]山东省疾病预防控制中心 [4]山东大学公共卫生学院

出　　处：《医学动物防制》2024年第7期724-727,共4页Journal of Medical Pest Control

基　　金：泰山学者青年专家计划项目(tsqn202103187)。

摘　　要：目的调查某中年女性发生肝脓肿、肺炎支原体感染与注射新型冠状病毒灭活疫苗的关系。方法县乡两级专业人员于2021年6月25日—7月10日开展个案调查,提取受种方、疫苗生产企业和接种方相关资料。市级预防接种异常反应调查诊断专家组于2021年8月2日对该疑似预防接种异常反应(adverse events following immunization,AEFI)病例开展调查诊断,并做出诊断意见。结果该病例于2021年5月6日9:40接种新型冠状病毒灭活疫苗,留观30min内无异常。于2021年5月14日—6月19日以“发热”为主诉,先后在三家医院住院治疗,住院期间行肝脏穿刺液培养诊断为肺炎克雷白杆菌阳性,血生化检验结果显示肺炎支原体抗体-免疫球蛋白M(immunoglobulin M,IgM)阳性,多次检测新型冠状病毒核酸结果均阴性。出院诊断主要为肝脓肿、双侧肺炎、感染性发热。疫苗质量合格,预防接种过程符合操作规程。市级调查诊断结论为偶合症。结论该病例接种新型冠状病毒灭活疫苗与肺炎支原体、肺炎克雷白杆菌感染的发生无因果关系,诊断为接种疫苗的偶合感染。Objective To investigate the relationship between the occurrence of liver abscess and Mycoplasma pneumoniae infection and the inactivated SARS-CoV-2 vaccination in a middle-aged female.Methods The county and village level carried out a case study from June 25 to July 10,2021,and collected the relevant data of the vaccine recipient,vaccine manufacturer,and vaccinators.The municipal expert group for investigation and diagnosis of adverse events following immunization(AEFI)carried out investigation and diagnosis of the suspected case and made diagnosis opinions on August 2,2021.Results The case received the inactivated SARS-CoV-2 vaccination at 9:40 on May 6,2021,and no abnormality was observed within 30 minutes.From May 14 to June 19,2021,the patient was hospitalized in three hospitals with"fever"as her main complaint.During hospitalization,the patient was diagnosed as Klereviella pneumoniae positive by liver puncture fluid culture,the blood biochemical test results showed Mycoplasma pneumoniae antibody-immunoglobulin M(IgM)positive,and nucleic acid the results of multiple tests for SARS-CoV-2 were negative.The main discharged diagnoses were liver abscess,bilateral pneumonia,and infectious fever.The quality of the vaccine was qualified,and the vaccination process was in accordance with the operating procedures.The conclusion of municipal investigation and diagnosis was coupling disease.Conclusion There is no causal relationship between the inactivated SARS-CoV-2 vaccination and the occurrence of the infection of Mycoplasma pneumoniae and Klebsiella pneumoniae in this case,and it is judged to be a conjugate infection of vaccination.

关 键 词：新型冠状病毒灭活疫苗 肺炎 预防接种 偶合症 流行病学 

分 类 号：R392-33[医药卫生—免疫学]