AkT/mTOR/Wnt/β-catenin/BMP信号通路的肌骨共生作用及其中药干预研究进展  

Muscle-bone crosstalk and the research progress on the intervention of traditional Chinese medicine in signaling pathways such as AkT/mTOR/Wnt/β-catenin/BMP

作　　者：刘晏东 邓强[2] 张彦军[2] 李中锋[2] 彭冉东 王雨榕 陈博 杨军[1] 杜健强 LIU Yandong;DENG Qiang;ZHANG Yanjun;LI Zhongfeng;PENG Randong;WANG Yurong;CHEN Bo;YANG Jun;DU Jianqiang(Gansu University of Traditional Chinese Medicine,Lanzhou 730000;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃省中医院,甘肃兰州730050

出　　处：《中国骨质疏松杂志》2024年第6期900-904,920,共6页Chinese Journal of Osteoporosis

基　　金：甘肃省联合科研基金(23JRRA1534);兰州市科技计划项目(2022-3-30)。

摘　　要：如果肌肉和骨骼同时发生衰减,则预示着生命出现不良结局的风险增高,将这种疾病称为肌少-骨质疏松症,而其对人体的危害远远大于单纯的肌肉衰减或骨质流失。虽然学术界对肌骨串扰和肌骨共减展开了较多的研究,但临床中仍然严重缺乏安全可靠的直接疗法以同时靶向肌肉和骨骼。鉴于该病对人类健康的巨大威胁,开发出具有肌骨共生作用的药物已刻不容缓。中药作为中国传统医学防病治病的主要手段,被广泛运用于各种慢性疾病。其中,一些中药不仅能调控肌肉系统,而且对骨骼系统也有显著的影响。该文基于AkT/mTOR/Wnt/β-catenin/BMP信号通路探讨既成肌又成骨的中药及其活性成分在该领域的作用和应用。If muscle and bone decay occur simultaneously,it indicates an increased risk of adverse outcomes in life.We refer to this disease as sarcopenia osteoporosis,and its harm to the human body is far greater than simple muscle decay or bone loss.Although the academic community has conducted extensive research on muscle bone crosstalk and muscle bone co reduction,there is still a serious lack of safe and reliable direct therapies in clinical practice to target both muscle and bone simultaneously.Given the enormous threat this disease poses to human health,it is urgent to develop drugs with muscle bone symbiotic effects.Traditional Chinese medicine,as the main means of disease prevention and treatment in traditional Chinese medicine,is widely used in various chronic diseases.Among them,some traditional Chinese medicines not only regulate the muscle system,but also have significant effects on the skeletal system.This article will be based on AkT/mTOR/Wnt/β-Exploring the Catenin/BMP signaling pathway and the role and application of traditional Chinese medicine and its active ingredients in both muscle and bone formation in this field.

关 键 词：肌少-骨质疏松症 肌骨共生 中药活性成分 信号通路 

分 类 号：R589[医药卫生—内分泌] R28[医药卫生—内科学]