双歧杆菌调控骨质疏松症作用机制研究进展  

Research progress on the mechanism of bifidobacterium regulating osteoporosis

作　　者：李想 孔令俊[2] 邓叶龙 张金磊 韩升龙 孟汉杰 王植帅 孙兴翔 LI Xiang;KONG Lingjun;DENG Yelong;ZHANG Jinlei;HAN Shenglong;MENG Hanjie;WANG Zhishuai;SUN Xingxiang(Gansu University of Traditional Chinese Medicine,Lanzhou 730000;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃省中医院,甘肃兰州730050

出　　处：《中国骨质疏松杂志》2024年第6期921-925,共5页Chinese Journal of Osteoporosis

基　　金：甘肃省中医药管理局项目(GZKP-2020-19);兰州市人才创新创业项目(2023-2-20)。

摘　　要：肠道菌群作为人体内最重要的微生物群落,可参与调控多种生理病理过程。其中双歧杆菌作为肠道中的主要益生菌之一,在维持人体健康中发挥重要作用,随着对其研究不断深入,发现双歧杆菌与骨代谢平衡密切相关,进而影响骨质疏松症发生发展。笔者检索国内外相关文献对双歧杆菌及其代谢产物通过调控M1/M2巨噬细胞极化、“Breg-Treg-Th17”细胞轴、肠道炎症、维生素D吸收以及骨形态发生蛋白-2、富含半胱氨酸型酸性蛋白等相关基因表达维持骨代谢平衡进行综述,旨在为进一步研究骨质疏松症提供参考和依据。As the most important microbial community in human body,intestinal flora can be involved in regulating various physiological and pathological processes.Bifidobacterium,as one of the main probiotics in the gut,plays an important role in maintaining human health.With the continuous deepening of research on bifidobacterium,it has been found that it is closely related to bone metabolic balance,thus affecting the occurrence and development of osteoporosis.In this paper,relevant literature at home and abroad was searched to review the maintenance of bone metabolic balance by bifidobacterium and its metabolites through regulation of M1/M2 macrophage polarization,“Breg-Treg-Th17”cell axis,intestinal inflammation,vitamin D absorption,and expression of bone morphogenetic protein-2,cysteine-rich acidic protein and other related genes.The aim is to provide reference and basis for further research on osteoporosis.

关 键 词：肠道菌群 双歧杆菌 骨质疏松 骨代谢 

分 类 号：R589.5[医药卫生—内分泌]