替格瑞洛对血清尿酸水平的影响及其机制的研究进展  

Research progress on the effects of ticagrelor on serum uric acid levels and its mechanisms

作　　者：周子涵 刘德敏[1] 崔炜[1] Zhou Zihan;Liu Demin;Cui Wei(Department of Cardiology,the Second Hospital of Hebei Medical University and Institute of Cardiocerebrovascular Disease of Hebei Province,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第二医院心内科、河北省心脑血管病研究所,石家庄050000

出　　处：《中国心血管杂志》2024年第3期263-268,共6页Chinese Journal of Cardiovascular Medicine

摘　　要：高尿酸血症是导致心血管疾病患者预后不良的重要原因。研究表明,替格瑞洛会引起不同程度的血清尿酸水平升高,可能与肾尿酸转运体功能障碍和红细胞腺苷再摄取减少相关。本文就替格瑞洛引起尿酸升高的发生率、危险因素和潜在机制等研究现状进行综述,旨在为替格瑞洛相关高尿酸血症的防治提供策略。Hyperuricemia is a significant determinant of poor prognosis in patients with cardiovascular disease.Numerous studies have demonstrated varying degrees of elevation in serum uric acid levels during ticagrelor administration,potentially attributed to impaired function of renal uric acid transporter and decreased reuptake of adenosine by erythrocyte.This review provides an overview of the incidence,risk factors,as well as potential mechanisms underlying ticagrelor-induced hyperuricemia,aiming to offer therapeutic strategies for the prevention and management of ticagrelor-related hyperuricemia.

关 键 词：替格瑞洛 尿酸 高尿酸血症 研究进展 

分 类 号：R969[医药卫生—药理学]