动脉粥样硬化斑块组织驻留巨噬细胞的研究进展  

Research progress on tissue-resident macrophages in atherosclerotic plaques

作　　者：方霆锋 江敏 胡炎伟 Fang Tingfeng;Jiang Min;Hu Yanwei(College of Pediatrics,Guangzhou Medical University,Guangzhou 510120,China;Department of Laboratory Medicine,Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510063,China)

机构地区：[1]广州医科大学儿科学院,510120 [2]广州医科大学附属妇女儿童医疗中心检验科,510063

出　　处：《中国心血管杂志》2024年第3期283-288,共6页Chinese Journal of Cardiovascular Medicine

基　　金：国家自然科学基金(82301906、82072335)。

摘　　要：巨噬细胞是动脉粥样硬化病理发生发展过程中的主要免疫细胞。动脉粥样硬化斑块组织驻留巨噬细胞(TRMs)的起源、发育、更新途径和作用机制尚有诸多未知。本文梳理了动脉粥样硬化斑块中TRMs的来源、特点和其在动脉粥样硬化发病中的多方面作用,以期为动脉粥样硬化寻找新的治疗途径提供理论依据。Macrophages play a crucial role in the pathogenesis and development of atherosclerosis.The origin,development,renewal pathways,and mechanisms of action of tissue-resident macrophages(TRMs) in atherosclerotic plaque tissues remain largely unknown.This article reviews the origin,characteristics,and multifaceted roles of TRMs in the pathogenesis of atherosclerosis,aiming to provide theoretical basis for exploring new therapeutic approaches for atherosclerosis.

关 键 词：动脉粥样硬化 组织驻留巨噬细胞 炎症 免疫机制 

分 类 号：R543.5[医药卫生—心血管疾病]