血清β-catenin、E-cadherin水平与糖尿病肾病患者钙磷代谢、颈动脉钙化的关系  

Relationship between serum levels of E-cadherin andβ-catenin and calcium phosphorus metabolism and carotid artery calcification in patients with diabetic nephropathy

作　　者：高剑[1] 梁铮 赵飞 刘小静 马宁 GAO Jian;LIANG Zheng;ZHAO Fei;LIU Xiaojing;MA Ning(First Department of Nephrology,Cangzhou Central Hospital,Cangzhou,Hebei 061000,China)

机构地区：[1]沧州市中心医院肾内一科,河北沧州061000

出　　处：《国际检验医学杂志》2024年第12期1469-1473,共5页International Journal of Laboratory Medicine

基　　金：沧州市重点研发计划指导项目(213106061)。

摘　　要：目的探讨血清E-钙黏蛋白(E-cadherin)、β-连环蛋白(β-catenin)水平与糖尿病肾病患者钙磷代谢、颈动脉钙化的关系。方法选择2019年5月至2022年11月该院收治的112例糖尿病肾病患者作为研究组,并根据双侧颈动脉彩超检查结果分为颈动脉钙化组(n=44)和非颈动脉钙化组(n=68),另选同期于该院接受体检的90例体检健康者为对照组。检测并比较各组血清E-cadherin、β-catenin及钙磷代谢水平,采用Pearson相关分析血清E-cadherin、β-catenin水平与糖尿病肾病患者钙磷代谢的关系,采用受试者工作特征(ROC)曲线评估血清E-cadherin、β-catenin对糖尿病肾病患者颈动脉钙化的预测价值,采用多因素Logistic回归分析糖尿病肾病患者颈动脉钙化的影响因素。结果研究组糖化血红蛋白、血磷、钙磷乘积、甲状旁腺激素(iPTH)、肌酐、碱性磷酸酶、β-catenin水平均高于对照组,E-cadherin水平低于对照组(P<0.05)。颈动脉钙化组血磷、血钙、钙磷乘积、iPTH、肌酐、碱性磷酸酶、β-catenin水平均高于非颈动脉钙化组,E-cadherin水平低于非颈动脉钙化组(P<0.001)。Pearson相关分析显示,糖尿病肾病患者血清E-cadherin与血磷、血钙、钙磷乘积、iPTH、肌酐、碱性磷酸酶均呈负相关(r=-0.453、-0.654、-0.365、-0.490、-0.411、-0.377,均P<0.05),血清β-catenin水平与血磷、血钙、钙磷乘积、iPTH、肌酐、碱性磷酸酶均呈正相关(r=0.444、0.345、0.421、0.398、0.651、0.622,均P<0.001)。ROC曲线分析显示,血清E-cadherin、β-catenin及二者联合预测糖尿病肾病颈动脉钙化的曲线下面积分别为0.844(95%CI 0.795~0.894)、0.853(95%CI 0.801~0.901)、0.901(95%CI 0.851~0.952)。多因素Logistic回归分析显示,血清E-cadherin(OR=3.789,95%CI 2.055~6.983)、β-catenin(OR=4.104,95%CI 1.795~9.385)、钙磷乘积(OR=2.998,95%CI 1.895~4.743)、iPTH(OR=2.713,95%CI 1.787~4.118)均是糖尿病肾病患者颈动脉钙化的影响因素(P<0.05)。结�Objective To investigate the relationship between serum levels of E-cadherin andβ-catenin and calcium phosphorus metabolism and carotid artery calcification in patients with diabetic nephropathy.Methods A total of 112 patients with diabetic nephropathy admitted to the hospital from May 2019 to November 2022 were selected as the study group,and were divided into a carotid artery calcification group(n=44)and a non-carotid artery calcification group(n=68)according to the results of bilateral carotid artery color Doppler ultrasound.In addition,90 healthy people who underwent physical examination in the hospital during the same period were selected as the control group.Serum E-cadherin,β-catenin,calcium phosphorus metabolism levels were detected and compared.Pearson correlation analysis was used to explore the relationship between serum E-cadherin,β-catenin and calcium phosphorus metabolism in patients with diabetic nephropathy.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of serum E-cadherin andβ-catenin for carotid artery calcification in patients with diabetic nephropathy.Multivariate Logistic regression analysis was used to explore the influencing factors of carotid artery calcification in patients with diabetic nephropathy.Results The levels of glycosylated hemoglobin,serum phosphorus,calcium-phosphorus product,parathyroid hormone(iPTH),creatinine,alkaline phosphatase andβ-catenin in the study group were higher than those in the control group,and the level of E-cadherin was lower than that in the control group(P<0.05).The levels of serum phosphorus,serum calcium,calcium phosphorus product,iPTH,creatinine,alkaline phosphatase andβ-catenin in the carotid artery calcification group were higher than those in the non-carotid artery calcification group,and the level of E-cadherin was lower than that in the non-carotid artery calcification group(P<0.05).Pearson correlation analysis showed that serum E-cadherin level in patients with diabetic nephropathy was negatively correl

关 键 词：糖尿病肾病 E-钙黏蛋白 Β-连环蛋白 钙磷代谢 颈动脉钙化 

分 类 号：R587.2[医药卫生—内分泌]