脂肪酸受体GPR119在动物脂代谢调控中的作用研究进展  

Role of Fatty Acid Receptor GPR119 in Lipid Metabolism of Animals

作　　者：艾庆辉[1,2] 刘国滨 卜宪勇 王震[1,2] 麦康森[1,2] Ai Qinghui;Liu Guobin;Bu Xianyong;Wang Zhen;Mai Kangsen(Key Laboratory of Aquaculture Nutrition and Feed of Ministry of Agriculture and Rural Affairs,Ocean University of China,Qingdao 266003,China;Key Laboratory of Mariculture(Ocean University of China),Ministry of Education,Qingdao 266003,China)

机构地区：[1]中国海洋大学农业农村部水产动物营养与饲料重点实验室,山东青岛266003 [2]海水养殖教育部重点实验室(中国海洋大学),山东青岛266003

出　　处：《中国海洋大学学报（自然科学版）》2024年第7期123-129,共7页Periodical of Ocean University of China

基　　金：国家自然科学基金重点项目(31830103)资助。

摘　　要：中国是水产养殖大国,而高脂饲料的广泛使用导致了鱼类脂肪代谢异常,这严重制约了水产养殖业的发展,亟待对此问题寻求解决方案。近年来在哺乳动物中的研究表明,脂代谢紊乱诱导的非酒精性脂肪肝病(Non-alcoholic fatty liver disease, NAFLD)是危害动物健康的主要问题之一,而GPR119被认为是治疗NAFLD的新靶点。GPR119在鱼类中的研究相对较少,大部分鱼类GPR119功能相关研究主要聚焦于其在调控鱼类食欲中的作用,而其在调控鱼类脂肪代谢中的作用尚不清楚。本文总结了动物中GPR119基因的结构功能及其对脂肪代谢调控机制的研究现状,旨在为研究GPR119在鱼类脂肪代谢中的作用提供新思路,为探索缓解鱼类脂代谢紊乱的新型策略提供理论参考。Aquaculture is a significant industry in China;however,the use of high-fat feed has led to the abnormal fat metabolism in fish,which has become a major hindrance to aquacultural development.Therefore,there is an urgent need to pave the ways of mitigating this issue.Current researches on mammals demonstrated that non-alcoholic fatty liver disease(NAFLD)associating with lipid metabolism disorders has become a major health hazard,and GPR119 is a new target for the treatment of NAFLD.However,the research related to GPR119 is scarce in fish,and most studies related to GPR119 have focused on its role in regulating fish appetite rather than its role in regulating fish fat metabolism homeostasis.Hence,we summarized recent advances in the structure and function of GPR119 gene.We also discussed the role of GPR119 in regulating lipid metabolism,which may serve as a reference for exploring new strategies of alleviating lipid metabolism disorders of fish.

关 键 词：GPR119 脂肪异常沉积 脂代谢 鱼类 

分 类 号：S963.731[农业科学—水产养殖]