基于数据挖掘探讨钱文燕教授治疗寻常性银屑病的用药规律  

Experience of Professor Qian Wenyan in treating psoriasis vulgaris based on data mining

作　　者：庄明月 罗莎 刘青武 杨顶权[3] ZHUANG Mingyue;LUO Sha;LIU Qingwu;YANG Dingquan(Graduate School of Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学研究生院,北京100029 [2]湖南中医药大学第一附属医院皮肤科 [3]中日友好医院皮肤病与性病科

出　　处：《实用皮肤病学杂志》2024年第2期111-117,共7页Journal of Practical Dermatology

摘　　要：目的基于数据挖掘探讨首都国医名师钱文燕教授治疗寻常性银屑病的遣方用药规律。方法收集2019年6月至2020年12月中日友好医院钱文燕教授诊治寻常性银屑病的中药处方,建立处方数据库,利用Microsoft Excel2016软件对处方药物进行频次、功效、性味及归经的分析,利用SPSS Statistics 26.0对高频药物进行聚类分析和采用SPSS Modeler18.0对药物进行关联规则分析,总结治疗寻常性银屑病的常用单药及药对,挖掘组方规律。结果共纳入82首治疗寻常性银屑病的方剂,涉及中药134味,单药以半枝莲、生地黄最为常用,清热凉血药占比最多。药味多以苦、甘为主,药性以寒多见,入肝经药出现频次最高。聚类分析得到3组药物组合。结论“从血论治、清热凉血”为钱文燕教授治疗寻常性银屑病的主要思路,善用清热凉血药,甘苦合化清热养阴。Objective To explore the prescription regularity of Professor Qian Wenyan,a renowned Chinese medicine practitioner,in the treatment of psoriasis vulgaris based on data mining.Methods This study compiled a prescription database of psoriasis vulgaris treatments administered by Professor Qian Wenyan at the China-Japan Friendship Hospital from June 2019 to December 2020.The frequency,eficacy,properties,and channel tropism of prescription herbals were analyzed using Microsoft Excel 2016 software.High-frequency herbals were subjected to cluster analysis using SPSS Statistics 26.0,while association rules of herbals were analyzed using SPSS Modeler 18.0.A comprehensive analysis was finally conducted to identify the commonly used single herbals and herbal pairs in the treatment of psoriasis vulgaris,as well as to explore the prescription regularity.Results The study encompassed a total of 82 prescriptions for the treatment of psoriasis vulgaris,involving 134 traditional Chinese medicines.The most commonly used Chinese medicinal herbs were Herba Scutellariae Barbatae and Rehmannia Glutinosa Libosch,with the highest proportion attributed to herbals for heat-clearing and blood-cooling purposes.The medicinal flavors predominantly exhibited bitter and sweet,while the medicinal properties primarily manifested as coldness;the channel tropism of herbals was mainly focused on the liver meridian.Herbal cluster analysis resulted in three distinct clustering prescriptions.Conclusion The primary approach employed by Professor Qian Wenyan in the treatment of psoriasis vulgaris focuses on"treating from blood,heat-clearing and blood-cooling"The Professor Qian skillfully utilizes heat-clearing and blood-cooling herbals,employing a combination of sweet and bitter flavors to effectively alleviate heat while simultaneously nourishing yin.

关 键 词：银屑病 寻常性 数据挖掘 中药处方 用药规律 

分 类 号：R758.63[医药卫生—皮肤病学与性病学] R275[医药卫生—临床医学]