抗感颗粒治疗小儿上呼吸道感染有效性和安全性的Meta分析  

Efficacy and Safety of Kanggan Granules in the Treatment of Upper Respiratory Tract Infections in Children:A Meta-analyse

作　　者：徐龙辰 韩千禧 潘婕 周平达 魏嘉茵 朱文涛[1] XU Long-Chen;HAN Qian-Xi;PAN Jie;ZHOU Ping-Da;WEI Jia-Yin;ZHU Wen-Tao(School of Management,Beijing University of Chinese Medicine,Beijing 102488,China)

机构地区：[1]北京中医药大学管理学院,北京102488

出　　处：《中国药物经济学》2024年第4期43-51,55,共10页China Journal of Pharmaceutical Economics

基　　金：中央高校基本科研业务专项(2020-JYB-ZDGG-072)。

摘　　要：目的系统评价抗感颗粒治疗小儿上呼吸道感染的有效性与安全性。方法以“抗感颗粒”“Kang Gan Granule”等为检索词,全面检索中国期刊全文数据库、中国生物医学文献服务系统、万方数据知识服务平台、中文期刊全文数据库、PubMed、Cochrane Library、Springer Link、Web of Science等中英文数据库,同时手动检索相关的会议论文,检索时间为建库至2023年6月,筛选抗感颗粒治疗小儿上呼吸道感染的随机对照试验(RCT),借助RevMan5.4软件进行Meta分析。结果根据纳入与排除标准进行筛选,最终纳入文献16篇,共计2287例患儿。Meta分析结果显示,相对于对照组,抗感颗粒组治疗小儿上呼吸道感染的总有效率更高(P<0.05),临床症状发热消失时间、临床症状肺内啰音消失时间更短(P<0.05),但临床症状咳嗽消失时间、不良反应发生率与对照组比较差异无统计学意义(P>0.05)。结论抗感颗粒疗效确切,可以有效缓解小儿上呼吸道感染患儿的症状,具有一定优势且安全性较好。但本研究所纳入文献的数量较少,证据强度有限,上述结论仍需更多高质量研究加以验证。Objective To systematically evaluate the effectiveness and safety of Kanggan Granules in the treatment of upper respiratory tract infections in children.Methods Using"Kanggan Granule"and"Kang Gan Granule"as search terms,a comprehensive search was conducted on Chinese and English databases such as PubMed,Cochrane Library,Springer Link,Web of Science,CNKI,SinoMed,WanFang,and VIP,as well as relevant journals and conference papers.The search was conducted until June 2023.A randomized controlled trial(RCT)was conducted to screen for the treatment of pediatric upper respiratory tract infections with Kanggan granules,and meta-analysis was conducted using RevMan 5.4 software.Results 16 randomized controlled trials met the inclusion criteria,with a total of2287 patients.The Meta results showed that compared to the control group,the Kanggan Granule group had a higher overall effective rate in treating upper respiratory tract infections in children,with shorter time for the disappearance of clinical symptoms such as fever and lung rales(P<0.05).However,there was no statistical difference in the disappearance time of clinical symptoms such as cough and the incidence of adverse reactions between the two groups(P>0.05).Conclusion Kanggan Granule has a definite therapeutic effect and can effectively alleviate the symptoms of upper respiratory tract infections in children.It has certain advantages and good safety.However,the number of literature included in this study is relatively small,and the evidence strength is limited.The above conclusions still need to be verified by more high-quality research.

关 键 词：抗感颗粒 小儿上呼吸道感染 META分析 有效性 安全性 

分 类 号：R725.6[医药卫生—儿科] R985[医药卫生—临床医学]