支气管哮喘急性发作期患儿血清PGRN、SFRP1、CCL26与肺功能和气道炎症的相关性研究  

Study on the Correlation between Serum PGRN,SFRP1,CCL26,Lung Function,and Airway Inflammation in Children with Acute Exacerbation of Bronchial Asthma

作　　者：连其昌 许晓丹 庄娇容 郑志宏 卢蔚薇 LIAN Qi-chang;XU Xiao-dan;ZHUANG Jiao-rong;ZHENG Zhi-hong;LU Wei-wei(Department of Pediatrics,The 909th Hospital/Dongnan Hospital of Xiamen University,Zhangzhou,Fujian,363000,China)

机构地区：[1]第九〇九医院/厦门大学附属东南医院儿科,福建漳州363000

出　　处：《现代生物医学进展》2024年第10期1860-1863,共4页Progress in Modern Biomedicine

基　　金：福建省科技厅科研基金项目(20180349)。

摘　　要：目的:分析支气管哮喘急性发作期患儿血清颗粒蛋白前体(PGRN)、分泌型卷曲相关蛋白1(SFRP1)、趋化因子配体26(CCL26)与肺功能和气道炎症的相关性。方法:选择2019年7月~2022年12月期间我院收治的支气管哮喘急性发作期患儿129例(急性组),根据肺功能检查并结合临床特点,将患儿分为轻度组(n=51)、中度组(n=42)和重度组(n=36)。另选取同期来我院治疗的支气管哮喘临床缓解期患儿60例(对照组),对比对照组和各急性组亚组的血清PGRN、SFRP1、CCL26、肺功能、气道炎症,采用Pearson相关性分析血清PGRN、SFRP1、CCL26与肺功能指标和气道炎症指标的相关性。结果:重度组、中度组、轻度组的PGRN低于对照组,SFRP1、CCL26则高于对照组(P<0.05)。且随着病情严重程度的增加,支气管哮喘儿童的PGRN不断下降,SFRP1、CCL26不断升高(P<0.05)。重度组、中度组、轻度组的用力肺活量(FVC)、第1秒用力呼气容积(FEV1)和最大呼气峰值流速(PEF)低于对照组(P<0.05)。且随着病情严重程度的增加,支气管哮喘儿童的FVC、FEV1、PEF不断下降(P<0.05)。重度组、中度组、轻度组的白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、白介素-17(IL-17)高于对照组(P<0.05)。且随着病情严重程度的增加,支气管哮喘儿童的IL-8、TNF-α、IL-17不断升高(P<0.05)。Pearson相关性分析结果显示,PGRN与肺功能指标呈正相关,与气道炎症指标呈负相关(P<0.05)。SFRP1、CCL26与肺功能指标呈负相关,与气道炎症指标呈正相关(P<0.05)。结论:支气管哮喘急性发作期患儿血清PGRN异常降低,SFRP1、CCL26异常升高,参与病情程度加重,且与肺功能和气道炎症相关。Objective:To analyze the correlation between serum progranulin(PGRN),secreted frizzled related protein1(SFRP1),chemokine cytokines ligand 26(CCL26),lung function,and airway inflammation in children with acute exacerbation of bronchial asthma.Methods:129 children with acute exacerbation of bronchial asthma(acute group)who were treated in our hospital from July 2019 to December 2022 were selected.According to lung function examination and combined with clinical characteristics,the children were divided into mild group(n=51),moderate group(n=42)and severe group(n=36).And another 60 children with clinical remission of bronchial asthma(control group)who came to our hospital for treatment during the same period were selected.The serum PGRN,SFRP1,CCL26,lung function and airway inflammation of children with bronchial asthma in the control group and each subgroup of acute group were compared.Pearson correlation was used to analyze the correlation between serum PGRN,SFRP1,CCL26 and lung function indexes and airway inflammation indexes.Results:The PGRN in the severe group,moderate group and mild group was lower than that in the control group,SFRP1 and CCL26 were higher than that in the control group(P<0.05).With the increase of the severity of the disease,the PGRN of children with bronchial asthma decreased continuously,and SFRP1 and CCL26 increased continuously(P<0.05).Forced vital capacity(FVC),forced expiratory volume in the first second(FEV_1)and maximum peak expiratory flow rate(PEF)in the severe group,moderate group and mild group were lower than those in the control group(P<0.05).FVC,FEV_1and PEF in children with bronchial asthma decreased continuously with the increase of the severity of the disease(P<0.05).The interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)and interleukin-17(IL-17)in the severe group,moderate group and mild group were higher than those in the control group(P<0.05).The IL-8,TNF-αand IL-17 in children with bronchial asthma increased continuously with the increase of the severity of the disease(

关 键 词：支气管哮喘 急性发作期 PGRN SFRP1 CCL26 肺功能 气道炎症 相关性 

分 类 号：R562.25[医药卫生—呼吸系统]