慢性乙型肝炎临床治愈的中国实践、治疗策略和展望  

Therapeutic strategies,practice,and prospect of a clinical cure for chronic hepatitis B in China

作　　者：莫志硕[1] 谢冬英[1] 林炳亮[1] 窦晓光[2] 万谟彬 江家骥[4] 赵英仁[5] 唐红[6] 庄辉 高志良[1] Mo Zhishuo;Xie Dongying;Lin Bingliang;Dou Xiaoguang;Wan Mobin;Jiang Jiaji;Zhao Yingren;Tang Hong;Zhuang Hui;Gao Zhiliang(Department of Infectious Diseases,Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China;Department of Infectious Diseases,Shengjing Hospital of China Medical University,Shenyang 110000,China;Department of Infectious Diseases,Shanghai Changhai Hospital,Shanghai 200082,China;Liver Research Center,First Affiliated Hospital of Fujian Medical University,Fuzhou 350000,China;Department of Infectious Diseases,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China;Center of Infectious Diseases,West China Hospital,Sichuan University,Chengdu 610041,China;Department of Microbiology and Infectious Disease Center,Peking University,Beijing 100000,China)

机构地区：[1]中山大学附属第三医院感染科,广州510630 [2]中国医科大学附属盛京医院感染科,沈阳110000 [3]上海长海医院感染科,上海200082 [4]福建医科大学附属第一医院肝病中心,福州350000 [5]西安交通大学第一附属医院感染科,西安710061 [6]四川大学华西医院感染性疾病中心,成都610041 [7]北京大学医学部病原生物学系和感染病中心,北京100000

出　　处：《中华肝脏病杂志》2024年第5期411-417,共7页Chinese Journal of Hepatology

基　　金："十三五"国家科技重大专项(2018ZX10302204-002);国家自然科学基金(82170612);广州市科技计划项目(2023B01J1007)。

摘　　要：临床治愈(又称功能性治愈)是目前国内外慢性乙型肝炎(CHB)防治指南公认的理想治疗目标。我国在CHB临床治愈研究探索及临床实践中已取得较丰富的成果,基于聚乙二醇干扰素α的治疗策略可有效提升临床治愈率。不同临床分型人群临床治愈策略的总结与优化、临床治愈持久性及远期结局的探索,对于CHB临床治愈的发展具有重要意义。解决目前存在的瓶颈问题将是我们未来努力的方向。Clinical cure(herein referred to as functional cure)is currently recognized as the ideal therapeutic goal by the guidelines for the prevention and treatment of chronic hepatitis B(CHB)at home and abroad.China has achieved significant results in research and exploration based on pegylated interferon alpha therapeutic strategies to promote the effectiveness of CHB clinical cure rates in clinical practice.The summary and optimization of clinical cure strategies in different clinical type classifications,as well as the exploration of clinical cure continuity and long-term outcomes,are of great significance for solving the current bottleneck problem and our future efforts in the developmental directions of clinical cure in CHB populations.

关 键 词：慢性乙型肝炎 预后 临床治愈 功能性治愈 临床实践 治疗策略 干扰素 核苷(酸)类似物 

分 类 号：R512.62[医药卫生—内科学]