类风湿性关节炎患者健康相关生命质量评价及其影响因素  

Assessmentof health-related quality of life and its influencing factors analysis in the inpatientswith rheumatoid arthritis based on EQ-5D-5L scale

作　　者：王善萍[1] 罗曼[1] 吴先琴[1] 田丹丹 王鹏 WANG Shanping;LUO Man;WU Xianqin;TIAN Dandan;WANG Peng(Department of Rheumatology and Immunology,the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230031,China;Teaching Center for Preventive Medicine,School of Public Health,Anhui Medical University,Hefei 230032,China)

机构地区：[1]安徽中医药大学第一附属医院风湿免疫科,安徽合肥230031 [2]安徽医科大学公共卫生学院预防医学教学中心,安徽合肥230032

出　　处：《安徽医学》2024年第6期778-782,共5页Anhui Medical Journal

基　　金：安徽省教育厅高校自然科学研究重点项目(编号:2022AH050653)。

摘　　要：目的探讨类风湿性关节炎(RA)住院患者健康相关生命质量(HRQoL)评分及其影响因素。方法采用欧洲五维度五水平健康量表(EQ-5D-5L)及自编问卷对2023年4~9月安徽中医药大学第一附属医院风湿免疫科收治的200例RA住院患者进行HRQoL调查,EQ-5D-5L量表中健康描述系统及视觉模拟标尺(EQ-VAS)分别用于测量RA患者健康效用值及整体健康状态,采用单因素分析、Tobit多因素回归分析影响RA患者HRQoL的因素。结果共收集190份有效问卷,有效回收率95%。RA患者健康效用值为(0.77±0.25),EQ-VAS评分为(76.44±43.65)分,其健康问题多集中于“行动能力”和“疼痛或不适”两个维度。Tobit多因素回归分析显示,文化程度低(P=0.042,95%CI:0.032~0.143)与吸烟(P=0.013,95%CI:-0.154~-0.019)是RA患者HRQoL的危险因素。结论RA患者HRQoL与EQ-VAS较一般人群相比情况尚可,但仍存在健康效用值较低的问题,其中文化程度低与吸烟的患者HRQoL较差。Objective Todiscussthe health-related quality of life(HRQoL)in inpatients with rheumatoid arthritis(RA)and analyze its influencing factors.Methods From April to September 2023,the survey was conducted using the European Quality of Life Five Dimension Five Level Scale(EQ-5D-5L)and a self-designed questionnaire on200 RA inpatientsat the Department of Rheumatology and Immunology in the First Affiliated Hospital of Anhui University of Traditional Chinese.The health description system and the European Quality Visual Analogue Scale(EQ-VAS)of EQ-5D-5Lwere used to measure the health utility and overall health status scores of RA patients,respectively.The influencing factors on HRQoL of RA patients were analyzed using t-test or One-way ANOVA,and Tobit regression model analysis was conducted to analyze the effects of basic information,clinical manifestations,and laboratoryindexesonHRQoL of RA patients.Results A total of 190 valid questionnaires were collected,with an effective recovery of 95%,the health utility value of RA patients was(0.77±0.25),and the value of EQ-VASwas(76.44±43.65).The health-related problems of RA patients mainly focused on the two dimensions of mobility and pain or discomfort.Tobit multivariable regression analysis showed that the lowerlevel of education(P=0.042,95%CI:0.032~0.143)and smoking(P=0.013,95%CI:-0.154~-0.019)represented as risk factors affecting HRQoLin RA patients.Conclusions The overall HRQoL and EQ-VAS in RA patients are generally good as compared to the general population,but there are still problemswith lower health utility values.Patients with lower education levels and smoking habits have poorHRQoL.

关 键 词：类风湿性关节炎 健康相关生命质量 健康效用值 欧洲五维度五水平健康量表 

分 类 号：R593.22[医药卫生—内科学]