Coexisting fast–slow dendritic traveling waves in a 3D-array electric field coupled neuronal network  

作　　者：魏熙乐 任泽宇 卢梅丽 樊亚琴 常思远 Xile Wei;Zeyu Ren;Meili Lu;Yaqin Fan;Siyuan Chang(The Tianjin Key Laboratory of Process Measurement and Control,School of Electrical and Information Engineering,Tianjin University,Tianjin 300072,China;School of Information Technology Engineering,Tianjin University of Technology and Education,Tianjin 300074,China)

机构地区：[1]The Tianjin Key Laboratory of Process Measurement and Control,School of Electrical and Information Engineering,Tianjin University,Tianjin 300072,China [2]School of Information Technology Engineering,Tianjin University of Technology and Education,Tianjin 300074,China

出　　处：《Chinese Physics B》2024年第6期614-626,共13页中国物理B（英文版）

基　　金：supported in part by the National Natural Science Foundation of China (Grant Nos. 62171312 and 61771330);the Tianjin Municipal Education Commission Scientific Research Project (Grant No. 2020KJ114)。

摘　　要：Coexistence of fast and slow traveling waves without synaptic transmission has been found in hhhippocampal tissues,which is closely related to both normal brain activity and abnormal neural activity such as epileptic discharge. However, the propagation mechanism behind this coexistence phenomenon remains unclear. In this paper, a three-dimensional electric field coupled hippocampal neural network is established to investigate generation of coexisting spontaneous fast and slow traveling waves. This model captures two types of dendritic traveling waves propagating in both transverse and longitude directions: the N-methyl-D-aspartate(NMDA)-dependent wave with a speed of about 0.1 m/s and the Ca-dependent wave with a speed of about 0.009 m/s. These traveling waves are synaptic-independent and could be conducted only by the electric fields generated by neighboring neurons, which are basically consistent with the in vitro data measured experiments. It is also found that the slow Ca wave could trigger generation of fast NMDA waves in the propagation path of slow waves whereas fast NMDA waves cannot affect the propagation of slow Ca waves. These results suggest that dendritic Ca waves could acted as the source of the coexistence fast and slow waves. Furthermore, we also confirm the impact of cellular spacing heterogeneity on the onset of coexisting fast and slow waves. The local region with decreasing distances among neighbor neurons is more liable to promote the onset of spontaneous slow waves which, as sources, excite propagation of fast waves. These modeling studies provide possible biophysical mechanisms underlying the neural dynamics of spontaneous traveling waves in brain tissues.

关 键 词：hippocampal network EPILEPTIFORM dendritic oscillation traveling wave electric field coupling 

分 类 号：R338[医药卫生—人体生理学]