卟啉基金属有机框架在光疗领域的应用  

Porphyrinoid-based metal-organic framework for phototherapy application

作　　者：徐赟浩 邓文博 冯亚青[1,2,3] 张宝 XU Yunhao;DENG Wenbo;FENG Yaqing;ZHANG Bao(School of Chemical Engineering and Technology,Tianjin University,Tianjin 300350,China;Tianjin Collaborative Innovation Centre of Chemical Science and Engineering,Tianjin 300072,China;Material Green Creation and Manufacturing Haihe Laboratory,Tianjin 300192,China)

机构地区：[1]天津大学化工学院,天津300350 [2]天津化学化工协同创新中心,天津300072 [3]物质绿色创造与制造海河实验室,天津300192

出　　处：《精细化工》2024年第6期1221-1229,1291,共10页Fine Chemicals

基　　金：国家自然科学基金项目(22078241);中央高校基本科研业务费专项资金;物质绿色创造与制作海河实验室项目。

摘　　要：卟啉基金属有机框架是金属或金属团簇与卟啉配体或其家族化合物配位自组装形成的晶体结构,结合了卟啉类分子良好的光物理特性和生物相容性,具有周期性和可调控的结构,在光化学领域和生物医药领域具有应用潜力;尤其是能够充分发挥卟啉类分子的优越性能,可通过光动、光热等光辅助治疗方法实现杀伤有害细胞的效果。该文介绍了卟啉基金属有机框架的结构,综述了卟啉基金属有机框架在光辅助治疗领域的最新研究进展,主要包括其在光疗抗肿瘤及抗菌领域的应用研究现状,重点介绍了近几年卟啉基金属有机框架在光敏剂基础上的改进以及衍生出的多样化的功能;最后,对其未来发展前景进行了展望。Porphyrinoid-based metal organic framework,featured with a crystal structure formed by the coordinating self-assembly between metal clusters and porphyrin ligand or porphyrinoid family compounds,has shown promising application potential in the field of photochemistry and biological medicine due to its combination of good photophysical properties and biocompatibility of porphyrinoid molecules as well as its periodic and controllable structure.In particular,with the excellent performance of porphyrinoid molecules fully utilized,the porphyrinoid metal organic framework plays an important role in killing harmful cells in human bodies with adjunctive photo-assisted therapy including photokinetic and photothermal treatments.Herein,the structure of porphyrinoid-based metal organic framework was introduced,followed by summarization on the recent development of porphyrinoid-based metal organic framework in the biomedical field including anti-tumor and anti-bacterial treatments.The performance improvement of porphyrinoid-based metal organic framework type photosensitizers in comparison to porphyrinoid molecules,and the diverse functions derived from the different type of porphyrinoid metal organic framework were emphatically discussed.Finally,the future development potentials of porphyrinoid metal organic framework were also proposed.

关 键 词：卟啉 金属有机框架 光辅助治疗 抗肿瘤 抗菌性能 

分 类 号：R318[医药卫生—生物医学工程] O641.4[医药卫生—基础医学]