刺激响应型脂质体的构建策略及其生物学应用  

Construction strategy of stimuli-responsive liposome and its biological application

作　　者：高欣茹 许文涛[2] GAO Xinru;XU Wentao(School of Food Science and Nutrition Engineering,China Agricultural University,Beijing 100083,China;Key Laboratory of Food Precision Nutrition and Quality Control of the Ministry of Education,Department of Nutrition and Health,China Agricultural University,Beijing 100083,China)

机构地区：[1]中国农业大学食品科学与营养工程学院,北京100083 [2]中国农业大学营养与健康系,食品精准营养与质量控制教育部重点实验室,北京100083

出　　处：《生物工程学报》2024年第6期1742-1751,共10页Chinese Journal of Biotechnology

基　　金：国家自然科学基金(21927812);秦皇岛市科学技术研究与发展计划项目(201903B002);未来功能性食品研发计划项目(SJ2021002006);北京市科技新星计划(20230484463)。

摘　　要：刺激响应型脂质体作为一种新型纳米载体,已广泛应用于医学、食品及化妆品领域。本文围绕刺激响应型脂质体的制备方式、构建策略及其生物学应用展开了详细的介绍。其中,重点综述了pH敏感型、氧化还原敏感型、酶敏感型、热敏型、光敏型和磁场响应型脂质体的功能原理,并根据给药方式的不同对其应用进行了总结归纳。最后,本文对当前刺激响应型脂质体面临的问题与发展前景作出了概括展望。Stimuli-responsive liposomes,a novel type of nanocarriers,have been widely used in the fields of medicine,food,and cosmetics.This paper provides a comprehensive introduction to the preparation methods,construction strategies,and biological applications of stimuli-responsive liposomes.The review highlights the functional principles of pH-sensitive,redox-sensitive,enzyme-sensitive, heat-sensitive, light-sensitive, and magnetic field-responsive liposomes, and summarizes their applications based on various drug delivery mode. Finally, the article provides an overview of the current challenges and future development prospects for stimuli-responsive liposomes.

关 键 词：刺激响应 脂质体 构建策略 给药方式 药物递送 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R943[医药卫生—药剂学]