脂肪间充质干细胞外泌体在妇科疾病的应用及进展  

Application and Progress of Adipose Derived Mesenchymal Stem Cell Exosomes in Gynecological Diseases

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作  者:石丽娟 于晓川 王化丽 SHI Li-juan;YU Xiao-chuan;WANG Hua-li(Dalian Medical University,Dalian 116000,Liaoning Province,China;Department of Gynecology,Dalian Women and Children′s Medical Group,Dalian116000,Liaoning Province,China)

机构地区:[1]大连医科大学,116000 [2]大连市妇女儿童医疗中心妇科

出  处:《国际妇产科学杂志》2024年第3期274-278,共5页Journal of International Obstetrics and Gynecology

基  金:大连市科技创新基金(2022JJ13SN086)。

摘  要:随着干细胞研究的发展,脂肪间充质干细胞(adipose derived mesenchymal stem cell,ADSC)和脂肪间充质干细胞外泌体(adipose derived mesenchymal stem cell exosome,ADSC-Exo)成为妇科领域的研究热点。ADSC是一类来源于脂肪组织的间充质干细胞,与其他间充质干细胞一样具有较高的增殖能力和多向分化潜能,ADSC-Exo还可通过释放的细胞外囊泡传递各种生物活性分子,如微小RNA、蛋白质和细胞因子,对目标细胞发挥一定的调节作用。ADSC-Exo在妇科领域的应用日益受到关注。有研究表明,ADSC-Exo可以促进子宫内膜的再生和修复,为宫腔粘连和不孕症的患者带来了希望。此外,一些研究提到ADSC-Exo在慢性子宫内膜炎、卵巢功能不全、多囊卵巢综合征和妇科恶性肿瘤等疾病的治疗中也具有一定的潜力。综述ADSC-Exo在妇科领域的应用及进展。With the development of stem cell research,adipose derived mesenchymal stem cell(ADSC)and adipose derived mesenchymal stem cell exosome(ADSC-Exo)have become a hot research topic in the field of gynecology.ADSC,a type of adipose-derived mesenchymal stem cells,has high proliferative capacity and multidirectional differentiation potential like other mesenchymal stem cells.ADSC-Exo can deliver a variety of biologically active molecules,such as microRNAs,proteins,and cytokines through released extracellular vesicles to play a certain regulatory role in the target cells.The application of ADSC-Exo in gynecology has also received increasing attention.Some studies have shown that ADSC-Exo can promote endometrial regeneration and repair,bringing hope to patients with intrauterine adhesion and infertility.In addition,some studies mentioned that ADSC-Exo also has potential in the treatment of chronic endometritis,ovarian insufficiency,polycystic ovary syndrome and gynecological malignancies.This paper reviews the application and advancements of ADSC-Exo in gynecology.

关 键 词:间质干细胞 外泌体 生殖器疾病 女(雌)性 治疗 脂肪间充质干细胞外泌体 

分 类 号:R711[医药卫生—妇产科学]

 

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