泌尿生殖道感染患者淋球菌感染的流行特征与耐药性探究  

Epidemiological characteristics and drug resistance of gonococcal infection in patients with urogenital tract infection

作　　者：郑晓伟 臧岱 李晓鸣 Zheng Xiao-wei;Zang Dai;Li Xiao-ming(Department of Clinical Laboratory,Puyang Hospital of Traditional Chinese Medicine,Puyang 457000,Henan,China)

机构地区：[1]濮阳市中医医院检验科,河南濮阳457000

出　　处：《四川生理科学杂志》2024年第6期1273-1275,1388,共4页Sichuan Journal of Physiological Sciences

摘　　要：目的:探讨泌尿生殖道感染中的淋球菌感染流行特征与耐药性特点。方法:选择2021年4月至2023年4月本院收治的82例泌尿生殖道感染患者,收集生殖道分泌物对淋球菌进行检测,并对阳性标本开展药敏试验。分析泌尿生殖道感染中的淋球菌感染流行特征与耐药性特点。结果:82例泌尿生殖道感染患者中有35例淋球菌检出结果为阳性,感染率为42.68%。男性患者中淋球菌感染率为56.60%(30/53),女性为17.24%(5/29)。不同性别泌尿生殖道感染患者淋球菌感染率比较差异有统计学意义(P<0.05)。21~30岁的淋球菌感染率最高,为53.85%,其次为31~40岁、41~50岁,淋球菌感染率分别为47.05%、33.33%,不同年龄阶段泌尿生殖道感染患者淋球菌感染率比较有统计学意义(P<0.05)。2021年(32.14%)、2022年(44.19%)、2023年(63.64%)淋球菌感染率逐年升高,但不同年份泌尿生殖道感染患者淋球菌感染率比较无统计学意义(P>0.05)。药敏试验结果显示,淋球菌对青霉素(65.71%)、四环素(91.43%)、环丙沙星(97.14%)的耐药率较高;对头孢西丁、头孢噻肟、头孢克肟、头孢呋肟的敏感性最佳,均为100%,其次为大观霉素(94.29%)、阿奇霉素(91.43%)、头孢曲松钠(77.14%)。结论:本地区泌尿生殖道感染患者淋球菌感染率较高且逐年上升,男性、21~40岁是感染高危人群,淋球菌对不同抗菌药物的耐药性各不相同。Objective:To investigate gonococcal infection's prevalence and drug resistance in urogenital tract infection.Methods:A total of 82 patients with urinary and reproductive tract infections admitted to our hospital from April 2021 to April 2023 were selected.Reproductive tract secretions were collected to detect Neisseria gonorrhoeae,and the positive specimens were subjected to drug sensitivity testing.The epidemiological and antibiotic resistance characteristics of Neisseria gonorrhoeae infection in urogenital tract infections were analyzed.Results:Among 82 patients with urogenital tract infection,35 cases were positive for gonococcus,and the infection rate was 42.68%.The incidence of gonococcal infection was 56.60%(30/53)in males and 17.24%(5/29)in females.There was a significant difference in gonococcal infection rate among different sex patients with urogenital tract infection(P<0.05).The highest gonococcal infection rate was 53.85%in patients aged 21-30,47.05%in patients aged 31-40,and 33.33%in patients aged 41-50,respectively.There was a significant statistical difference in the gonococcal infection rate in patients with urogenital tract infection at different ages(P<0.05).Gonococcal infection rate increased yearly in 2021(32.14%),2022(44.19%),and 2023(63.64%),but there was no significant statistical difference in patients with urogenital tract infection in different years(P>0.05).The results of the drug sensitivity test showed that the resistance rate of gonococcus to penicillin(65.71%),tetracycline(91.43%),and ciprofloxacin(97.14%)was high.The sensitivity to cefoxitin,cefotaxime,cefixime,and cefuroxime was the best,all of which were 100%,followed by spectinomycin(94.29%),azithromycin(91.43%)and ceftriaxone sodium(77.14%).Conclusion:The gonococcal infection rate in patients with urogenital tract infection in this region is high and increasing yearly.Males and aged 21-40 years old are in the high-risk groups for infection.The resistance of gonococcal to different antibacterial drugs is different.

关 键 词：泌尿生殖道感染 淋球菌 流行特征 耐药性 

分 类 号：R691.3[医药卫生—泌尿科学]