丙型肝炎持续病毒学应答后肝癌发生的危险因素及预测模型  

Risk factors and predictive models for liver cancer after sustained virologic response in hepatitis C

作　　者：许姗姗[1] 仇丽霞[1] 柳雅立[1] 张晶[1] XU Shanshan;QIU Lixia;LIU Yali;ZHANG Jing(Third Department of Liver Disease Center,Beijing YouAn Hospital,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学附属北京佑安医院肝病中心三科,北京100069

出　　处：《临床肝胆病杂志》2024年第6期1259-1263,共5页Journal of Clinical Hepatology

基　　金：2022年度院内中青年人才孵育项目(BJYAYY-YN2022-02)。

摘　　要：丙型肝炎是肝癌发生的主要病因之一。随着直接抗病毒药物的应用,95%以上的患者可根除HCV,获得持续病毒学应答(SVR)。有效的抗病毒治疗可以改变丙型肝炎的自然病程,降低肝癌发生风险,但仍有一部分患者会受到年龄、性别、肝纤维化、糖尿病、肝脂肪变、饮酒和遗传因素等影响,成为肝癌高危人群。因此,如何识别和预测丙型肝炎SVR后肝癌高危人群需进一步明确与完善。本文通过系统综述丙型肝炎患者SVR后肝癌发生的危险因素和肝癌预测模型,旨在为临床识别丙型肝炎SVR后肝癌高风险人群提供依据。Hepatitis C is one of the main causes of liver cancer.With the application of direct-acting antiviral agents,more than 95%of patients can achieve the eradication of hepatitis C virus and obtain sustained virologic response(SVR).Effective antiviral therapy can change the natural course of hepatitis C and reduce the risk of liver cancer;however,some patients are still affected by age,sex,liver fibrosis,diabetes,hepatic steatosis,alcohol consumption,and genetic factors and become the high-risk population of liver cancer.Therefore,it is needed to further clarify and improve the identification and prediction of high-risk populations of liver cancer after SVR of hepatitis C.This article reviews the risk factors and predictive models for liver cancer after SVR in patients with hepatitis C,in order to provide a basis for identifying the high-risk population of liver cancer after SVR of hepatitis C in clinical practice.

关 键 词：丙型肝炎 持续病毒学应答 肝肿瘤 危险因素 

分 类 号：R512.63[医药卫生—内科学] R735.7[医药卫生—临床医学]