ROS Balance Autoregulating Core-Shell CeO_(2)@ZIF-8/Au Nanoplatform for Wound Repair  

作　　者：Xi Zhou Quan Zhou Zhaozhi He Yi Xiao Yan Liu Zhuohang Huang Yaoji Sun Jiawei Wang Zhengdong Zhao Xiaozhou Liu Bin Zhou Lei Ren Yu Sun Zhiwei Chen Xingcai Zhang 

机构地区：[1]The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province,Research Center of Biomedical Engineering of Xiamen,Department of Biomaterials,College of Materials,Xiamen University,Xiamen 361005,People’s Republic of China [2]Department of Electronic Science,Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research,School of Electronic Science and Engineering,Xiamen University,Xiamen 361005,People’s Republic of China [3]John A Paulson School of Engineering and Applied Sciences,Harvard University,Cambridge,MA 02138,USA [4]Department of Otorhinolaryngology,Union Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,People’s Republic of China [5]NO.1 Middle School Affiliated to Central China Normal University,Wuhan 430223,People’s Republic of China

出　　处：《Nano-Micro Letters》2024年第8期341-361,共21页纳微快报（英文版）

基　　金：supported by the Natural Science Foundation of Fujian Province of China(No.2022J01043);China Scholarship Council(201806315005 and 201703170071).

摘　　要：Reactive oxygen species(ROS)plays important roles in living organisms.While ROS is a double-edged sword,which can eliminate drug-resistant bacteria,but excessive levels can cause oxidative damage to cells.A core–shell nanozyme,Ce O_(2)@ZIF-8/Au,has been crafted,spontaneously activating both ROS generating and scavenging functions,achieving the multifaceted functions of eliminating bacteria,reducing inflammation,and promoting wound healing.The Au Nanoparticles(NPs)on the shell exhibit high-efficiency peroxidase-like activity,producing ROS to kill bacteria.Meanwhile,the encapsulation of Ce O_(2) core within ZIF-8 provides a seal for temporarily limiting the superoxide dismutase and catalase-like activities of Ce O_(2) nanoparticles.Subsequently,as the ZIF-8 structure decomposes in the acidic microenvironment,the Ce O_(2) core is gradually released,exerting its ROS scavenging activity to eliminate excess ROS produced by the Au NPs.These two functions automatically and continuously regulate the balance of ROS levels,ultimately achieving the function of killing bacteria,reducing inflammation,and promoting wound healing.Such innovative ROS spontaneous regulators hold immense potential for revolutionizing the field of antibacterial agents and therapies.

关 键 词：Metal-organic framework(MOF) Reactive oxygen species(ROS) Cerium dioxide Au nanoparticles Wound healing 

分 类 号：R318[医药卫生—生物医学工程] TB383.1[医药卫生—基础医学]