甘精胰岛素与阿卡波糖片联合治疗老年糖尿病患者的临床效果探讨  

Clinical effect of combined treatment of insulin glargine and acarbose tablets on elderly patients with diabetes

作　　者：王伟凤 WANG Wei-feng(Endocrine Department,Laizhou People's Hospital,Laizhou 261400,China)

机构地区：[1]莱州市人民医院内分泌科,261400

出　　处：《中国现代药物应用》2024年第11期129-131,共3页Chinese Journal of Modern Drug Application

摘　　要：目的研究老年糖尿病患者应用甘精胰岛素与阿卡波糖片联合治疗的临床效果。方法80例接受治疗的老年糖尿病患者,使用随机数字表法分为对照组和观察组,每组40例。对照组采用二甲双胍与阿卡波糖片联合治疗,观察组采用甘精胰岛素与阿卡波糖片联合治疗。比较两组患者治疗效果,治疗前后的血糖指标、体质量指数及不良反应发生情况。结果观察组治疗总有效率100.00%明显高于对照组的87.50%,差异具有统计学意义(P<0.05)。治疗后,观察组患者空腹血糖为(5.96±0.57)mmol/L、餐后2 h血糖为(9.13±1.03)mmol/L、糖化血红蛋白为(5.12±1.57)%、体质量指数为(23.97±2.03)kg/m2,均优于对照组的(6.58±0.18)mmol/L、(11.41±2.53)mmol/L、(7.15±1.18)%、(25.52±2.53)kg/m2,差异具有统计学意义(P<0.05)。观察组不良反应发生率5.00%低于对照组的20.00%,差异具有统计学意义(P<0.05)。结论老年糖尿病患者采用甘精胰岛素与阿卡波糖片联合治疗效果显著,在临床中具有重要意义,值得广泛应用。Objective To study the clinical effect of the combination of insulin glargine and acarbose tablets in elderly patients with diabetes.Methods 80 elderly patients with diabetes were divided into a control group and an observation group according to random numerical table,with 40 cases in each group.The control group was treated with metformin combined with acarbose,and the observation group was treated with insulin glargine combined with acarbose tablets.The clinical effect,blood glucose and body mass index before and after treatment,adverse reactions of the two groups were compared.Results The observation group had total effective rate of 100.00%,which was significantly higher than 87.50%in the control group,and the difference was statistically significant(P<0.05).After treatment,the observation group had fasting blood glucose of(5.96±0.57)mmol/L,2 h postprandial blood glucose of(9.13±1.03)mmol/L,glycosylated hemoglobin of(5.12±1.57)%,and body mass index of(23.97±2.03)kg/m2,which were better than(6.58±0.18)mmol/L,(11.41±2.53)mmol/L,(7.15±1.18)%,and(25.52±2.53)kg/m2 in the control group.The difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 5.00%,which was lower than 20.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion The combined treatment of insulin glargine and acarbose tablets in elderly patients with diabetes has a significant effect,which is of great significance in clinical practice and is worth extensive application.

关 键 词：老年糖尿病 甘精胰岛素 阿卡波糖片 血糖 

分 类 号：R587.1[医药卫生—内分泌]